Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.68 |
| ▸ | HPGD | P15428 | 6/20 | 0.59 |
| ▸ | F2 | P00734 | 3/20 | 0.57 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.57 |
| ▸ | F10 | P00742 | 2/20 | 0.57 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.53 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.53 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.53 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.53 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.53 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.53 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.53 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.53 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.53 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.53 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 6/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4418893 | 0.85 | ALDH1A1 (0.75) | ALDH1A1HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11142367 | 0.82 | ALDH1A1 (0.74) | ALDH1A1HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL70639 | 0.81 | ALDH1A1 (1.00) | ALDH1A1HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6236939 | 0.80 | ALDH1A1 (0.68) | ALDH1A1HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL78465 | 0.78 | ALDH1A1 (0.65) | ALDH1A1HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL322211 | 0.78 | ALDH1A1 (0.93) | ALDH1A1HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL457785 | 0.78 | ALDH1A1 (0.75) | ALDH1A1HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12359037 | 0.78 | ALDH1A1 (0.75) | ALDH1A1HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27350108 | 0.78 | F2 (0.55) | ALDH1A1F2PRSS1F10PRSS2 | |
| SCHEMBL1656668 | 0.77 | ALDH1A1 (0.68) | ALDH1A1HPGDNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691953-B1 | 1-AMIDINOPHENYL-PYRROLIDONES/ PIPERIDINONES AS PLATELET AGGREGATION INHIBITORS | SEARLE & CO (US) | 2000-08-02 | — | — | EP | disclosed |
| US-6037365-A | ANTIINFLAMMATORY AND ANTIMETASTASIS AGENTS; CARDIOVASCULAR DISORDERS, ARTERIOSCLEROSIS | G.D. SEARLE & CO. (US) | 2000-03-14 | — | — | US | disclosed |
| US-5872122-A | Pyrimidinylamidino β-amino acid derivatives useful as inhibitors of platelet aggregation | MONSANTO COMPANY (US) | 1999-02-16 | — | — | US | disclosed |
| US-5721366-A | PHENYLAMIDINE DERIVATIVES | G. D. SEARLE & CO (US) | 1998-02-24 | — | — | US | disclosed |