Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 17/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PDE5A | O76074 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042386 | 0.84 | HIF1A (0.84) | HIF1AKDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL8049554 | 0.84 | HIF1A (0.66) | HIF1AGRM5KDM4ELMNAHTT | |
| SCHEMBL8651042 | 0.82 | HIF1A (0.52) | HIF1AGRM5 | |
| SCHEMBL30260200 | 0.82 | HIF1A (0.74) | HIF1AKDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL8043528 | 0.81 | GRM5 (0.50) | HIF1AMEN1NPC1KMT2AGRM5 | |
| SCHEMBL8043574 | 0.77 | KDM4E (0.67) | HIF1AKMT2AGRM5KDM4ELMNA | |
| SCHEMBL19911080 | 0.76 | HIF1A (1.00) | HIF1AKDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL29546979 | 0.76 | HIF1A (1.00) | HIF1AKDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL29853761 | 0.76 | HIF1A (1.00) | HIF1AKDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL8042401 | 0.74 | HIF1A (0.85) | HIF1AKDM4ELMNAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6159974-A | LDL receptor gene expression promoters | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | claimed |
| US-6159974-A | LDL receptor gene expression promoters | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | disclosed |