Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.67 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.48 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.45 |
| ▸ | MERTK | Q12866 | 2/20 | 0.45 |
| ▸ | GAS6 | Q14393 | 2/20 | 0.45 |
| ▸ | AXL | P30530 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043528 | 0.79 | GRM5 (0.50) | KDM4ELMNAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL8032052 | 0.77 | HIF1A (0.69) | KDM4ELMNAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL8049554 | 0.76 | HIF1A (0.66) | KDM4ELMNASLC2A1HTTSMN1; SMN2 | |
| SCHEMBL8651042 | 0.75 | HIF1A (0.52) | HIF1AGRM5CRHR1FLT3TYRO3 | |
| SCHEMBL2908412 | 0.71 | ACP1 (0.70) | KDM4ELMNAHSP90AA1SLC2A1HTT | |
| SCHEMBL6076972 | 0.68 | CRHR1 (0.47) | SMN1; SMN2CRHR1CNR1OPRL1 | |
| SCHEMBL2322004 | 0.67 | NPC1 (0.69) | KDM4ELMNAHSP90AA1HTTKMT2A | |
| SCHEMBL21573363 | 0.67 | GPR39 (0.56) | KDM4ELMNAHSP90AA1SLC2A1HTT | |
| SCHEMBL20402919 | 0.67 | GPR39 (0.56) | KDM4ELMNAHSP90AA1SLC2A1HTT | |
| SCHEMBL18557136 | 0.67 | GPR39 (0.56) | KDM4ELMNAHSP90AA1SLC2A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6159974-A | LDL receptor gene expression promoters | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | claimed |
| US-6159974-A | LDL receptor gene expression promoters | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | disclosed |