Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 12/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8032052 | 0.81 | HIF1A (0.69) | GRM5MEN1KMT2AHIF1ALMNA | |
| SCHEMBL8651042 | 0.80 | HIF1A (0.52) | GRM5HIF1A | |
| SCHEMBL8049554 | 0.80 | HIF1A (0.66) | GRM5HIF1ALMNAHTTSMN1; SMN2 | |
| SCHEMBL8043574 | 0.79 | KDM4E (0.67) | GRM5KMT2AHIF1ALMNAHTT | |
| SCHEMBL2322004 | 0.70 | NPC1 (0.69) | GRM5RAB9AMEN1KMT2AHIF1A | |
| SCHEMBL30821175 | 0.67 | GRM5 (1.00) | GRM5RAB9AMEN1KMT2ALMNA | |
| SCHEMBL28406354 | 0.67 | CBFB (0.53) | GRM5RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL18385896 | 0.67 | NPC1 (0.57) | GRM5RAB9ALMNAHTTSMN1; SMN2 | |
| SCHEMBL8045470 | 0.66 | NPC1 (0.47) | GRM5RAB9AMEN1KMT2AHIF1A | |
| SCHEMBL25418630 | 0.64 | CYP1A2 (0.43) | GRM5RAB9AKMT2ALMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6159974-A | LDL receptor gene expression promoters | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | claimed |
| US-6159974-A | LDL receptor gene expression promoters | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | disclosed |