Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | TAOK3 | Q9H2K8 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
| ▸ | TAOK1 | Q7L7X3 | 4/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.45 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2820245 | 0.93 | KMT2A (0.47) | KMT2AL3MBTL1TAOK3ALDH1A1DHODH | |
| SCHEMBL803556 | 0.93 | KMT2A (0.47) | KMT2AL3MBTL1TAOK3ALDH1A1DHODH | |
| SCHEMBL788668 | 0.88 | TAOK3 (0.47) | L3MBTL1TAOK3ALDH1A1DHODHTAOK1 | |
| SCHEMBL785295 | 0.88 | TAOK3 (0.47) | L3MBTL1TAOK3ALDH1A1DHODHTAOK1 | |
| SCHEMBL803234 | 0.84 | KMT2A (0.45) | KMT2AL3MBTL1TAOK3ALDH1A1DHODH | |
| SCHEMBL803498 | 0.84 | KMT2A (0.47) | KMT2AL3MBTL1TAOK3TAOK1HPGD | |
| SCHEMBL784523 | 0.81 | PDE4A (0.42) | KMT2ATAOK3ALDH1A1TAOK1HTT | |
| SCHEMBL785600 | 0.81 | PDE4A (0.42) | KMT2ATAOK3ALDH1A1TAOK1HTT | |
| SCHEMBL13918277 | 0.79 | ALDH1A1 (0.69) | L3MBTL1ALDH1A1USP2PLA2G1BATG4B | |
| SCHEMBL803516 | 0.78 | NAMPT (0.52) | KMT2ATAOK3ALDH1A1DHODHLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680159-B2 | Bradykinin 1 receptor modulating compounds | GRUENENTHAL GMBH (DE) | 2014-03-25 | — | — | US | disclosed |
| US-8680159-B2 | Bradykinin 1 receptor modulating compounds | GRUENENTHAL GMBH (DE) | 2014-03-25 | — | — | US | disclosed |
| WO-2012038081-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2012-03-29 | — | — | WO | disclosed |
| US-20120071461-A1 | Substituted Benzamide Compounds | GRUENENTHAL GMBH (DE) | 2012-03-22 | — | — | US | disclosed |
| US-20120071461-A1 | Substituted Benzamide Compounds | GRUENENTHAL GMBH (DE) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071461-A1 | Substituted Benzamide Compounds | BDKRB1, BDKRB2, HRH2 | KMT2A 2222/4885L3MBTL1 1325/4885TAOK3 2233/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.