Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glutamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.86 |
| ▸ | GRM8 | O00222 | 2/20 | 0.86 |
| ▸ | GRM6 | O15303 | 2/20 | 0.86 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.86 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.86 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.86 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.86 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.86 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.86 |
| ▸ | GRM5 | P41594 | 1/20 | 0.86 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.86 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.86 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.86 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.86 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.86 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.86 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.86 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.86 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.86 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Glutamate SCHEMBL8560542 | 1.00 | GSR (0.86) | GSRGRM8GRM6GRM7GRM4 | |
| D-Glutamate SCHEMBL8391023 | 1.00 | GSR (0.86) | GSRGRM8GRM6GRM7GRM4 | |
| Glutamic Acid SCHEMBL7616974 | 1.00 | GSR (0.86) | GSRGRM8GRM6GRM7GRM4 | |
| D-Glutamate SCHEMBL27602737 | 0.98 | GSR (0.82) | GSRGRM8GRM6GRM7GRM4 | |
| Glutamic Acid SCHEMBL17477271 | 0.94 | GSR (0.75) | GSRGRM8GRM6GRM7GRM4 | |
| Glutamic Acid SCHEMBL8775640 | 0.93 | GSR (0.82) | GSRGRM8GRM6GRM7GRM4 | |
| D-Glutamate SCHEMBL20212359 | 0.93 | GSR (0.82) | GSRGRM8GRM6GRM7GRM4 | |
| Glutamic Acid SCHEMBL156857 | 0.93 | GSR (0.82) | GSRGRM8GRM6GRM7GRM4 | |
| D-Glutamate SCHEMBL1330484 | 0.93 | GRM8 (1.00) | GSRGRM8GRM6GRM7GRM4 | |
| D-Glutamate SCHEMBL410241 | 0.93 | GRM8 (1.00) | GSRGRM8GRM6GRM7GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0642876-B1 | Bonding to nickel-titanium alloy | COOK INC (US) | 2000-03-15 | — | — | EP | claimed |
| CN-112675314-B | Bone-targeting nano micelle delivery system and preparation method thereof | 中国药科大学 | 2023-02-24 | — | — | CN | disclosed |
| CN-112675314-A | Bone-targeting nano micelle delivery system and preparation method thereof | 中国药科大学 | 2021-04-20 | — | — | CN | disclosed |
| CN-111448302-A | Low dusting particles | 诺维信公司 | 2020-07-24 | — | — | CN | disclosed |
| CN-103222036-B | Suspension, polishing liquid set, polishing liquid, method for polishing substrate, and substrate | 日立化成株式会社 | 2016-11-09 | — | — | CN | disclosed |
| EP-0642876-B1 | Bonding to nickel-titanium alloy | COOK INC (US) | 2000-03-15 | — | — | EP | disclosed |
| EP-0915131-A1 | Flame-retarded thermoplastic resin composition | Ajinomoto Co., Inc. (JP) | 1999-05-12 | — | — | EP | disclosed |
| EP-0642876-A1 | Bonding to nickel-titanium alloy | Cook Incorporated (US) | 1995-03-15 | — | — | EP | disclosed |
| US-5354623-A | Alloy substrate with titanium oxide-free surface, metal from metallic halide containing flux deposited thereon, solder material adhering to deposited metal | COOK INCORPORATED (US) | 1994-10-11 | — | — | US | disclosed |