Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of D-Glutamate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.86 |
| ▸ | GRM8 | O00222 | 2/20 | 0.86 |
| ▸ | GRM6 | O15303 | 2/20 | 0.86 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.86 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.86 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.86 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.86 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.86 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.86 |
| ▸ | GRM5 | P41594 | 1/20 | 0.86 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.86 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.86 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.86 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.86 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.86 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.86 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.86 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.86 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.86 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutamic Acid SCHEMBL8032708 | 1.00 | GSR (0.86) | GSRGRM8GRM6GRM7GRM4 | |
| D-Glutamate SCHEMBL8391023 | 1.00 | GSR (0.86) | GSRGRM8GRM6GRM7GRM4 | |
| Glutamic Acid SCHEMBL7616974 | 1.00 | GSR (0.86) | GSRGRM8GRM6GRM7GRM4 | |
| D-Glutamate SCHEMBL27602737 | 0.98 | GSR (0.82) | GSRGRM8GRM6GRM7GRM4 | |
| Glutamic Acid SCHEMBL17477271 | 0.94 | GSR (0.75) | GSRGRM8GRM6GRM7GRM4 | |
| Glutamic Acid SCHEMBL8775640 | 0.93 | GSR (0.82) | GSRGRM8GRM6GRM7GRM4 | |
| D-Glutamate SCHEMBL20212359 | 0.93 | GSR (0.82) | GSRGRM8GRM6GRM7GRM4 | |
| Glutamic Acid SCHEMBL156857 | 0.93 | GSR (0.82) | GSRGRM8GRM6GRM7GRM4 | |
| D-Glutamate SCHEMBL1330484 | 0.93 | GRM8 (1.00) | GSRGRM8GRM6GRM7GRM4 | |
| D-Glutamate SCHEMBL410241 | 0.93 | GRM8 (1.00) | GSRGRM8GRM6GRM7GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113677204-B | Use of protoporphyrin IX derivatives to improve plant health | 桑科能源股份有限公司 | 2024-03-05 | — | — | CN | disclosed |
| CN-115103593-A | Oxygen-impermeable porphyrin photosensitizer film compositions for application to plants | 森科尔能源有限公司 | 2022-09-23 | — | — | CN | disclosed |
| CN-113677204-A | Use of protoporphyrin IX derivatives for improving plant health | 桑科能源股份有限公司 | 2021-11-19 | — | — | CN | disclosed |
| US-5739093-A | DETERGENT CONTAINING ETHYLENE APARTIC GLUTAMIC ACID OR SALT THEREOF; IMPROVED STAIN REMOVAL | LEVER BROTHERS COMPANY, DIVISION OF CONOPCO, INC. (US) | 1998-04-14 | — | — | US | disclosed |
| US-5688996-A | DETERGENTS OR BUILDERS | LEVER BROTHERS COMPANY, DIVISION OF CONOPCO, INC. (US) | 1997-11-18 | — | — | US | disclosed |
| EP-0796842-A2 | Ethylene aspartate cysteate sequestrants, methods of producing them and detergent compositions containing them | UNILEVER PLC (GB) | 1997-09-24 | — | — | EP | disclosed |
| US-5668098-A | Detergent compositions containing ethylene aspartate cysteate (EAC) sequestrants | LEVER BROTHERS COMPANY, DIVISION OF CONOPCO, INC. (US) | 1997-09-16 | — | — | US | disclosed |