Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Glutamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.75 |
| ▸ | GRM8 | O00222 | 2/20 | 0.75 |
| ▸ | GRM6 | O15303 | 2/20 | 0.75 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.75 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.75 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.75 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.75 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.75 |
| ▸ | GRM5 | P41594 | 1/20 | 0.75 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.75 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.75 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.75 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.75 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.75 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.75 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.75 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.75 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.75 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Glutamate SCHEMBL28509459 | 0.94 | GRM8 (0.86) | GSRGRM8GRM6GRM7GRM4 | |
| Glutamic Acid SCHEMBL8032708 | 0.94 | GSR (0.86) | GSRGRM8GRM6GRM7GRM4 | |
| Glutamic Acid SCHEMBL2803034 | 0.94 | GRM8 (0.86) | GSRGRM8GRM6GRM7GRM4 | |
| D-Glutamate SCHEMBL184512 | 0.94 | GRM8 (0.86) | GSRGRM8GRM6GRM7GRM4 | |
| Glutamic Acid SCHEMBL7616974 | 0.94 | GSR (0.86) | GSRGRM8GRM6GRM7GRM4 | |
| D-Glutamate SCHEMBL15797537 | 0.94 | GRM8 (0.86) | GSRGRM8GRM6GRM7GRM4 | |
| D-Glutamate SCHEMBL8391023 | 0.94 | GSR (0.86) | GSRGRM8GRM6GRM7GRM4 | |
| Glutamic Acid SCHEMBL184513 | 0.94 | GRM8 (0.86) | GSRGRM8GRM6GRM7GRM4 | |
| D-Glutamate SCHEMBL8560542 | 0.94 | GSR (0.86) | GSRGRM8GRM6GRM7GRM4 | |
| D-Glutamate SCHEMBL27884184 | 0.94 | GRM8 (0.86) | GSRGRM8GRM6GRM7GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10479925-B2 | Use of hexamethylenetetramine intensifier for high temperature emulsified acid system | HALLIBURTON ENERGY SERVICES, INC. (US) | 2019-11-19 | — | — | US | disclosed |
| US-10301522-B2 | Sulfide stress cracking inhibitors | HALLIBURTON ENERGY SERVICES, INC. (US) | 2019-05-28 | — | — | US | disclosed |
| US-20170247601-A1 | METHOD FOR INHIBITING SULFIDE STRESS CRACKING OF METALS | HALLIBURTON ENERGY SERVICES, INC. (US) | 2017-08-31 | — | — | US | disclosed |
| US-20170233638-A1 | Use of Hexamethylenetetramine Intensifier for High Temperature Emulsified Acid System | HALLIBURTON ENERGY SERVICES, INC. (US) | 2017-08-17 | — | — | US | disclosed |
| US-20170121584-A1 | Sulfide Stress Cracking Inhibitors | HALLIBURTON ENERGY SERVICES, INC. (US) | 2017-05-04 | — | — | US | disclosed |
| US-9587157-B2 | Sulfide stress cracking inhibitors | HALLIBURTON ENERGY SERVICES, INC. (US) | 2017-03-07 | — | — | US | disclosed |
| US-20160272867-A1 | SULFIDE STRESS CRACKING INHIBITORS | HALLIBURTON ENERGY SERVICES, INC. | 2016-09-22 | — | — | US | disclosed |
| WO-2016060671-A1 | METHOD FOR INHIBITING SULFIDE STRESS CRACKING OF METALS | HALLIBURTON ENERGY SERVICES, INC. (US) | 2016-04-21 | — | — | WO | disclosed |
| WO-2016043703-A1 | USE OF HEXAMETHYLENETETRAMINE INTENSIFIER FOR HIGH TEMPERATURE EMULSIFIED ACID SYSTEM | HALLIBURTON ENERGY SERVICES, INC. (US) | 2016-03-24 | — | — | WO | disclosed |
| WO-2016018311-A1 | SULFIDE STRESS CRACKING INHIBITORS | HALLIBURTON ENERGY SERVICES, INC. (US) | 2016-02-04 | — | — | WO | disclosed |