Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 6/20 | 0.49 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.49 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | GPBAR1 | Q8TDU6 | 7/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8462384 | 0.81 | CYSLTR1 (0.44) | CYSLTR1CYSLTR2ALOX5GPBAR1PDE10A | |
| SCHEMBL8019571 | 0.80 | GRM5 (0.58) | GRM5 | |
| SCHEMBL8462301 | 0.80 | CYSLTR1 (0.44) | CYSLTR1CYSLTR2ALOX5GPBAR1PDE10A | |
| SCHEMBL8461158 | 0.80 | CYSLTR1 (0.49) | CYSLTR1CYSLTR2ALOX5GPBAR1 | |
| SCHEMBL8461147 | 0.80 | CYSLTR1 (0.49) | CYSLTR1CYSLTR2ALOX5GPBAR1 | |
| SCHEMBL8461154 | 0.80 | CYSLTR1 (0.49) | CYSLTR1CYSLTR2ALOX5GPBAR1 | |
| SCHEMBL8029124 | 0.78 | GPBAR1 (0.49) | CYSLTR1CYSLTR2ALOX5GPBAR1PDE10A | |
| SCHEMBL8032680 | 0.78 | GPBAR1 (0.49) | CYSLTR1CYSLTR2ALOX5GPBAR1PDE10A | |
| SCHEMBL8032678 | 0.78 | GPBAR1 (0.49) | CYSLTR1CYSLTR2ALOX5GPBAR1PDE10A | |
| SCHEMBL8029247 | 0.78 | ALOX5 (0.44) | CYSLTR1CYSLTR2ALOX5GPBAR1PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6166031-A | Substituted tetralins, chromans and related compounds in the treatment of asthma | PFIZER INC, (US) | 2000-12-26 | — | — | US | disclosed |
| US-5998451-A | LIPOXYGENASE INHIBITORS | PFIZER INC (US) | 1999-12-07 | — | — | US | disclosed |
| EP-0313295-B1 | SUBSTITUTED TETRALINS, CHROMANS AND RELATED COMPOUNDS IN THE TREATMENT OF ASTHMA, ARTHRITIS AND RELATED DISEASES | PFIZER INC. (US) | 1993-07-28 | — | — | EP | disclosed |
| US-5059609-A | Lipoxygenase inhibitors; leukotriene receptor blockers; psoriasis; antiulcer agents and myocardial infarctions | PFIZER INC. (US) | 1991-10-22 | — | — | US | disclosed |
| WO-1989003681-A1 | SUBSTITUTED TETRALINS, CHROMANS AND RELATED COMPOUNDS IN THE TREATMENT OF ASTHMA | PFIZER INC. (US) | 1989-05-05 | — | — | WO | disclosed |
| EP-0313296-A2 | Substituted chromans and related compounds in the treatment of asthma | PFIZER INC. (US) | 1989-04-26 | — | — | EP | disclosed |