SCHEMBL8032803

SCHEMBL8032803

CC[Si]1(c2ccc(C)cc2)CCC(=O)CC1

nearest known ligand 0.34

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 1/20 0.34
HSD11B1 P28845 1/20 0.31
CA1 P00915 1/20 0.30
CA2 P00918 1/20 0.30
CYP1A2 P05177 1/20 0.30
ELANE P08246 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17105813 0.80 ACHE (0.35)
SCHEMBL8021390 0.80 ACHE (0.35)
SCHEMBL7758786 0.70
P-Xylene SCHEMBL28227111 0.65 TRIM24 (0.59) MGLLCYP1A2ELANE
P-Xylene SCHEMBL21798505 0.64 TRIM24 (0.61) CYP1A2ELANE
SCHEMBL8021126 0.62 HRH3 (0.38)
P-Xylene SCHEMBL28011603 0.57 ACHE (0.57) MGLLCA1CA2ELANE
Toluene SCHEMBL10011124 0.56 LMNA (0.55) CYP1A2
Butane SCHEMBL15660794 0.56
P-Xylene SCHEMBL28331001 0.56 ACHE (0.67) CA1CA2CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0673942-B1 Silacyclohexanone compounds as intermediates for the preparation of silacyclohexane-type liquid cristal compounds SHINETSU CHEMICAL CO (JP) 2000-11-08 EP disclosed
EP-0682031-B1 Silacyclohexane-based carbaldehyde compounds and processes for preparing silacyclohexane-based liquid crystal compounds from the carbaldehyde compound SHINETSU CHEMICAL CO (JP) 2000-03-22 EP disclosed
US-5641431-A Silacyclohexanone compound and a method of preparing a silacyclohexane-type liquid crystal composition containing it SHIN-ETSU CHEMICAL CO., LTD. (JP) 1997-06-24 US disclosed
US-5527490-A Silacyclohexane carbaldehyde compounds and processes for preparing silacyclohexane-based liquid crystal compounds from the carbaldehyde compound SHIN-ETSU CHEMICAL CO., LTD. (JP) 1996-06-18 US disclosed
EP-0682031-A1 Silacyclohexane carbaldehyde compounds and processes for preparing silycyclohexane-based liquid crystal compounds from the carbaldehyde compound SHIN-ETSU CHEMICAL CO., LTD. (JP) 1995-11-15 EP disclosed
EP-0673942-A1 Silacyclohexanone compounds as intermediates for the preparation of silacyclohexane-type liquid cristal compounds Shin-Etsu Chemical Co., Ltd. (JP) 1995-09-27 EP disclosed