Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | RGS12 | O14924 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8033672 | 0.89 | NPSR1 (0.39) | ALDH1A1TSHRLMNARAB9AMAPK1 | |
| SCHEMBL8046221 | 0.83 | ALDH1A1 (0.51) | ALDH1A1TSHRLMNARAB9AMAPK1 | |
| SCHEMBL8042320 | 0.83 | L3MBTL1 (0.38) | ALDH1A1TSHRLMNAMAPK1HTT | |
| SCHEMBL8050069 | 0.82 | ALDH1A1 (0.45) | ALDH1A1TSHRLMNARAB9AMAPK1 | |
| SCHEMBL8043646 | 0.82 | ALDH1A1 (0.54) | ALDH1A1TSHRLMNARAB9AMAPK1 | |
| SCHEMBL8044897 | 0.81 | ALDH1A1 (0.45) | ALDH1A1LMNARAB9AMAPK1HTT | |
| SCHEMBL6749888 | 0.81 | MAPK8 (0.44) | ALDH1A1TSHRLMNARAB9AMAPK1 | |
| SCHEMBL8051020 | 0.80 | KDM4C (0.38) | ALDH1A1TSHRLMNARAB9AMAPK1 | |
| SCHEMBL8044080 | 0.79 | ALDH1A1 (0.40) | ALDH1A1LMNARAB9AMAPK1HTT | |
| SCHEMBL8051547 | 0.78 | KMT2A (0.48) | ALDH1A1TSHRLMNARAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |