Ditolylguanidine

Ditolylguanidine

SCHEMBL80339

Cc1ccccc1N=C(N)Nc1ccccc1C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 18/20 1.00
GRIN2D O15399 14/20 1.00
GRIN3B O60391 14/20 1.00
GRIN1 Q05586 14/20 1.00
GRIN2A Q12879 14/20 1.00
GRIN2B Q13224 14/20 1.00
GRIN2C Q14957 14/20 1.00
GRIN3A Q8TCU5 14/20 1.00
MEN1 O00255 1/20 1.00
PABPC1 P11940 1/20 1.00
ALOX15 P16050 1/20 1.00
TSHR P16473 1/20 1.00
KMT2A Q03164 1/20 1.00
EBP Q15125 1/20 1.00
TMEM97 Q5BJF2 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ditolylguanidine SCHEMBL29364709 1.00 SIGMAR1 (1.00) SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A
Ditolylguanidine SCHEMBL158674 1.00 SIGMAR1 (1.00) SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A
Ditolylguanidine SCHEMBL3388414 1.00 SIGMAR1 (1.00) SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A
Ditolylguanidine SCHEMBL8862769 0.98 SIGMAR1 (0.97) SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL8873081 0.87 SIGMAR1 (1.00) SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL8875387 0.87 SIGMAR1 (0.78) SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL8874196 0.84 SIGMAR1 (0.81) SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL8873792 0.84 SIGMAR1 (1.00) SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL14861883 0.83 SIGMAR1 (0.78) SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A
Hydrochloric Acid SCHEMBL8874645 0.83 SIGMAR1 (1.00) SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 417 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250066519-A1 ANTIMICROBIAL RUBBER COMPOSITION AND ARTICLES MADE THEREFROM GARWARE FULFLEX INDIA PVT LIMITED (IN) 2025-02-27 US claimed
US-20160017109-A1 LATEX COMPOSITION SOBELTEC (BE) 2016-01-21 US claimed
EP-2297232-B1 METHOD AND DEVICE FOR PRODUCING A CROSS-LINKABLE RUBBER MIXTURE RHEIN CHEMIE RHEINAU GMBH (DE) 2016-01-06 EP claimed
US-8846816-B2 Process and apparatus for the preparation of crosslinkable rubber mixtures RHEIN CHEMIE RHEINAU GMBH (DE) 2014-09-30 US claimed
WO-2014012979-A2 LATEX COMPOSITION SOBELTEC (BE) 2014-01-23 WO claimed
EP-2687629-A1 Latex composition Sobeltec (BE) 2014-01-22 EP claimed
US-7771641-B2 Component part with integrated seal FEDERAL MOGUL SEALING SYSTEMS BRETTEN GMBH (DE) 2010-08-10 US claimed
US-7765976-B2 Component part with integrated seal FEDERAL MOGUL SEALING SYSTEMS BRETTEN GMBH (DE) 2010-08-03 US claimed
EP-1491545-B1 Method of preparing a composite of hydrophobated amorphous silica employing blocked mercaptoalkoxysilanes GOODYEAR TIRE & RUBBER (US) 2009-01-14 EP claimed
US-7262254-B2 Tire with low volatile alcohol emission rubber tread with compositional limitations THE GOODYEAR TIRE & RUBBER COMPANY (US) 2007-08-28 US claimed
US-5483006-A PEPTIZED BY A XANTHOGEN DISULFIDE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1996-01-09 US claimed
US-5385946-A Method for treating hypertension with disubstituted granidine compounds STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION, ACTING FOR AND ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY AND THE UNIVERSITY OF OREGON (US) 1995-01-31 US claimed
US-5312840-A Substituted guanidines having high binding to the sigma receptor and the use thereof STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION (US) 1994-05-17 US claimed
EP-0532642-A4 1994-04-27 EP claimed
EP-0532642-A1 SUBSTITUTED GUANIDINES HAVING HIGH BINDING TO THE SIGMA RECEPTOR AND THE USE THEREOF STATE OF OREGON, acting through OREGON STATE BOARD OF HIGHER EDUCATION, acting for OREGON HEALTH SC. UNIV. AND UNIV. OF OREGON (US) 1993-03-24 EP claimed
WO-1991018868-A1 SUBSTITUTED GUANIDINES HAVING HIGH BINDING TO THE SIGMA RECEPTOR AND THE USE THEREOF STATE OF OREGON, acting by and through the OREGON STATE BOARD OF HIGHER EDUCATION, acting for and onbehalf of the OREGON HEALTH SCIENCES UNIVERSITY (US) 1991-12-12 WO claimed
EP-0314690-A4 SIGMA BRAIN RECEPTOR LIGANDS AND THEIR USE. OREGON STATE (US) 1989-11-07 EP claimed
EP-0314690-A1 SIGMA BRAIN RECEPTOR LIGANDS AND THEIR USE. OREGON STATE (US) 1989-05-10 EP claimed
US-4732925-A METALLURGICAL CARBON THE FIRESTONE TIRE & RUBBER COMPANY (US) 1988-03-22 US claimed
WO-1988000583-A1 SIGMA BRAIN RECEPTOR LIGANDS AND THEIR USE STATE OF OREGON ACTING BY AND THROUGH THE STATE BO (US) 1988-01-28 WO claimed