SCHEMBL8034045

SCHEMBL8034045

CC(C)(CC(=O)OO)c1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 1/20 0.50
HIF1A Q16665 1/20 0.50
ALDH1A1 P00352 2/20 0.45
TAAR1 Q96RJ0 1/20 0.45
ALOX15 P16050 1/20 0.45
MAPT P10636 1/20 0.42
KMT2A Q03164 1/20 0.42
ME2 P23368 2/20 0.42
ME1 P48163 2/20 0.42
ME3 Q16798 2/20 0.42
HTT P42858 1/20 0.42
KCNN4 O15554 1/20 0.41
HDAC3 O15379 1/20 0.40
HDAC4 P56524 1/20 0.40
HDAC1 Q13547 1/20 0.40
HDAC7 Q8WUI4 1/20 0.40
HDAC2 Q92769 1/20 0.40
HDAC10 Q969S8 1/20 0.40
HDAC11 Q96DB2 1/20 0.40
HDAC8 Q9BY41 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL156185 0.85 KCNN4 (0.50) CYP2C19HIF1AALDH1A1TAAR1ALOX15
SCHEMBL28660324 0.83 CYP2C19 (0.53) CYP2C19HIF1AALDH1A1TAAR1ALOX15
SCHEMBL8854205 0.81 CYP2C19 (0.52) CYP2C19HIF1AALDH1A1TAAR1ALOX15
SCHEMBL21447568 0.81 HSD11B1 (0.52) CYP2C19HIF1AALDH1A1TAAR1MAPT
SCHEMBL17599140 0.81 CYP2C19 (0.47) CYP2C19HIF1AALDH1A1TAAR1ALOX15
Acetic Acid SCHEMBL6405973 0.81 KCNN4 (0.47) CYP2C19HIF1AALDH1A1TAAR1ALOX15
SCHEMBL27755288 0.81 CYP2C19 (0.47) CYP2C19HIF1AALDH1A1TAAR1ALOX15
SCHEMBL57411 0.79 CYP2C19 (0.69) CYP2C19HIF1AALDH1A1TAAR1ALOX15
SCHEMBL20897116 0.79 LMNA (0.50) CYP2C19HIF1AALDH1A1TAAR1KMT2A
SCHEMBL8518160 0.79 CYP2C19 (0.44) CYP2C19HIF1AALDH1A1TAAR1ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2000068192-A2 PROCESS FOR THE PREPARATION OF (DI)ALKYLPEROXY ESTERS OF (DI)CARBOXYLIC ACIDS AKZO NOBEL N.V. (NL) 2000-11-16 WO disclosed
US-4075236-A FROM ACID CHLORIDE, A HYDROPEROXIDE AND AN ALKALI METAL HYDROXIDE PENNWALT CORPORATION (US) 1978-02-21 US disclosed