SCHEMBL8034197

SCHEMBL8034197

CCCC1CCC(CCc2ccc(-c3ccc(OC(F)(F)F)c(F)c3)cc2)CC1

nearest known ligand 0.45

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
NAAA Q02083 2/20 0.40
CTSK P43235 1/20 0.40
FFAR4 Q5NUL3 1/20 0.38
CYP17A1 P05093 1/20 0.37
HCRTR1 O43613 6/20 0.37
HCRTR2 O43614 6/20 0.37
S1PR1 P21453 1/20 0.36
EPHX2 P34913 3/20 0.36
RARB P10826 2/20 0.36
RARA P10276 1/20 0.36
RARG P13631 1/20 0.36
GPR84 Q9NQS5 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8748046 0.93 RARB (0.39) NAAACTSKFFAR4CYP17A1HCRTR1
SCHEMBL8747985 0.92 RARB (0.41) NAAACTSKFFAR4CYP17A1HCRTR1
SCHEMBL8747918 0.91 RARB (0.43) NAAACTSKFFAR4CYP17A1HCRTR1
SCHEMBL8748030 0.91 RARB (0.43) NAAACTSKFFAR4CYP17A1HCRTR1
SCHEMBL8018485 0.90 HCRTR1 (0.41) HCRTR1HCRTR2EPHX2
SCHEMBL8031029 0.89 HCRTR1 (0.41) HCRTR1HCRTR2EPHX2
SCHEMBL7770288 0.87 NAAA (0.36) NAAACTSKFFAR4CYP17A1HCRTR1
SCHEMBL8034592 0.87 EPHX2 (0.38) NAAACTSKFFAR4CYP17A1HCRTR1
SCHEMBL7770286 0.87 NAAA (0.36) NAAACTSKFFAR4CYP17A1HCRTR1
SCHEMBL8834365 0.87 CYP17A1 (0.33) NAAACTSKFFAR4CYP17A1S1PR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6013198-A LIQUID CRYSTALLINE COMPOUNDS MODIFIED TO HAVE A TRIFLUOROMETHYLPHENYL GROUP OR TRIFLUOROMETHOXYPHENYL GROUP AS EXAMPLE OF KNOWN TERMINAL SUBSTITUENT; CHEMICAL STABILITY, HIGH VOLTAGE HOLDING RATIO, GOOD UV STABILITY CHISSO CORPORATION (JP) 2000-01-11 US disclosed
EP-0761799-A1 Liquid crystalline compound substituted with fluorine containing group, liquid crystal composition, and liquid crystal display device Chisso Corporation (JP) 1997-03-12 EP disclosed