SCHEMBL8034605

SCHEMBL8034605

CC(C)C(NC(=O)O)(C(=O)C(Cl)Cl)c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.41
CYP2D6 P10635 2/20 0.41
MAPT P10636 2/20 0.37
HSP90AA1 P07900 1/20 0.37
GPR55 Q9Y2T6 1/20 0.37
KCNN4 O15554 1/20 0.36
CYP2C19 P33261 1/20 0.36
HIF1A Q16665 1/20 0.36
HDAC3 O15379 1/20 0.35
HDAC4 P56524 1/20 0.35
HDAC1 Q13547 1/20 0.35
HDAC7 Q8WUI4 1/20 0.35
HDAC2 Q92769 1/20 0.35
HDAC10 Q969S8 1/20 0.35
HDAC11 Q96DB2 1/20 0.35
HDAC8 Q9BY41 1/20 0.35
HDAC6 Q9UBN7 1/20 0.35
HDAC9 Q9UKV0 1/20 0.35
HDAC5 Q9UQL6 1/20 0.35
GAA P10253 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11035564 0.83 CYP1A2 (0.50) CYP1A2CYP2D6MAPTKCNN4CYP2C19
SCHEMBL8025041 0.74 GAA (0.38) CYP1A2CYP2D6MAPTHSP90AA1GPR55
SCHEMBL2364655 0.69 CYP1A2 (0.42) CYP1A2CYP2D6MAPTHSP90AA1GPR55
SCHEMBL27662931 0.68 CYP1A2 (0.44) CYP1A2CYP2D6MAPTHSP90AA1GPR55
SCHEMBL27159384 0.67 CYP1A2 (0.44) CYP1A2CYP2D6GAAKMT2A
SCHEMBL27159381 0.67 CYP1A2 (0.44) CYP1A2CYP2D6GAAKMT2A
SCHEMBL3249695 0.66 CYP1A2 (0.50) CYP1A2CYP2D6MAPTHSP90AA1GPR55
SCHEMBL935057 0.65 SSTR4 (0.53) CYP1A2MAPTKCNN4CYP2C19HIF1A
SCHEMBL28905042 0.65 HDAC3 (0.50) CYP1A2CYP2D6MAPTKCNN4CYP2C19
SCHEMBL9159682 0.64 KCNN4 (0.45) CYP1A2CYP2D6MAPTKCNN4CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6020518-A Process for preparing β-amino-α-hydroxy acid derivatives KANEKA CORPORATION (JP) 2000-02-01 US disclosed