Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 6/20 | 0.40 |
| ▸ | ESR1 | P03372 | 3/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | WEE1 | P30291 | 1/20 | 0.38 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | TMIGD3 | P0DMS9 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21357357 | 0.82 | ERN1 (0.39) | ERN1RPS6KB2MAPTTMIGD3ADORA2A | |
| SCHEMBL6067982 | 0.78 | MAPT (0.47) | ERN1ESR1ESR2CHEK1WEE1 | |
| SCHEMBL1823432 | 0.77 | LTA4H (0.43) | RPS6KB2MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL8034332 | 0.76 | MAOB (0.48) | ERN1MAPTSMN1; SMN2MEN1GAA | |
| SCHEMBL7157852 | 0.74 | ESR1 (0.57) | ERN1ESR1ESR2CHEK1WEE1 | |
| SCHEMBL27752649 | 0.74 | ESR2 (0.61) | ERN1ESR1ESR2MAPTSMN1; SMN2 | |
| SCHEMBL19153623 | 0.73 | ERN1 (0.54) | ERN1ESR1ESR2CHEK1WEE1 | |
| Cyanide SCHEMBL28839538 | 0.72 | LTA4H (0.40) | MAPTSMN1; SMN2MEN1GAAKMT2A | |
| SCHEMBL32674544 | 0.72 | ALOX5 (0.59) | ESR1ESR2KMT2AMIFNPC1 | |
| SCHEMBL28489946 | 0.71 | TNFRSF1A (0.37) | ERN1RPS6KB2MAPTADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009076166-A2 | OXIMYL HCV SERINE PROTEASE INHIBITORS | ENANTA PHARMACEUTICALS, INC. (US) | 2009-06-18 | — | — | WO | disclosed |
| WO-2009076173-A2 | FLUORINATED TRIPEPTIDE HCV SERINE PROTEASE INHIBITORS | ENANTA PHARMACEUTICALS, INC. (US) | 2009-06-18 | — | — | WO | disclosed |
| WO-2007146695-A1 | ACYCLIC OXIMYL HEPATITIS C PROTEASE INHIBITORS | ENANTA PHARMACEUTICALS, INC. (US) | 2007-12-21 | — | — | WO | disclosed |