Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.43 |
| ▸ | WNT1 | P04628 | 4/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 3/20 | 0.41 |
| ▸ | CLK3 | P49761 | 2/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | FES | P07332 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14235967 | 0.91 | BRAF (0.45) | BRAFDYRK1AWNT1CDK5CDK5R1 | |
| SCHEMBL1593931 | 0.85 | BRAF (0.62) | BRAF | |
| SCHEMBL1593253 | 0.78 | BRAF (0.61) | BRAF | |
| SCHEMBL1592858 | 0.73 | CNR2 (0.46) | DYRK1ACLK2CLK3KDR | |
| SCHEMBL14236417 | 0.73 | BRAF (0.48) | BRAFCLK2DYRK3PRKD3MAP4K4 | |
| SCHEMBL13705609 | 0.71 | CDK1 (0.54) | DYRK1ACDK5CLK2DYRK3PRKD3 | |
| SCHEMBL14236414 | 0.70 | BRAF (0.49) | BRAF | |
| SCHEMBL1592880 | 0.70 | BRAF (0.71) | BRAF | |
| SCHEMBL14236068 | 0.69 | BRAF (0.53) | BRAFDYRK1AWNT1CLK2DYRK3 | |
| SCHEMBL8032286 | 0.69 | BRAF (0.53) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111279-A1 | PYRAZOLE [3, 4-B] PYRIDINE RAF INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2009-09-11 | — | — | WO | disclosed |