Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 7/20 | 0.56 |
| ▸ | MAOB | P27338 | 4/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | METAP1 | P53582 | 1/20 | 0.55 |
| ▸ | MIF | P14174 | 3/20 | 0.53 |
| ▸ | CES2 | O00748 | 3/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.53 |
| ▸ | BCHE | P06276 | 2/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8034934 | 1.00 | ACHE (0.56) | ACHEMAOBMAOAMETAP1MIF | |
| SCHEMBL2424712 | 0.93 | MAOB (0.59) | ACHEMAOBMAOAMETAP1MIF | |
| SCHEMBL2424708 | 0.93 | MAOB (0.59) | ACHEMAOBMAOAMETAP1MIF | |
| SCHEMBL4808970 | 0.80 | MIF (0.61) | ACHEMAOBMAOAMETAP1MIF | |
| SCHEMBL4808965 | 0.80 | MIF (0.61) | ACHEMAOBMAOAMETAP1MIF | |
| SCHEMBL29038294 | 0.77 | CES2 (0.80) | ACHEMAOBMAOAMIFCES2 | |
| SCHEMBL29038289 | 0.77 | CES2 (0.80) | ACHEMAOBMAOAMIFCES2 | |
| SCHEMBL7787097 | 0.75 | MAOB (0.87) | ACHEMAOBMAOAMIFCES2 | |
| SCHEMBL30667154 | 0.75 | MAOB (0.87) | ACHEMAOBMAOAMIFCES2 | |
| SCHEMBL7787095 | 0.75 | MAOB (0.87) | ACHEMAOBMAOAMIFCES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6166031-A | Substituted tetralins, chromans and related compounds in the treatment of asthma | PFIZER INC, (US) | 2000-12-26 | — | — | US | disclosed |
| WO-1989003681-A1 | SUBSTITUTED TETRALINS, CHROMANS AND RELATED COMPOUNDS IN THE TREATMENT OF ASTHMA | PFIZER INC. (US) | 1989-05-05 | — | — | WO | disclosed |