Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 4/20 | 0.57 |
| ▸ | CYP26A1 | O43174 | 7/20 | 0.49 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.44 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8030964 | 0.86 | MEN1 (0.44) | CYP19A1CYP26A1PBRM1THRATHRB | |
| SCHEMBL8028175 | 0.81 | CYP19A1 (0.61) | CYP19A1CYP26A1NQO2MTNR1AMTNR1B | |
| SCHEMBL8756180 | 0.80 | CYP19A1 (0.58) | CYP19A1HTR1A | |
| SCHEMBL9638064 | 0.77 | CYP19A1 (0.64) | CYP19A1CYP26A1PBRM1CYP24A1ESR1 | |
| SCHEMBL28048794 | 0.77 | ESR1 (0.59) | CYP19A1NQO2MTNR1AMTNR1BESR1 | |
| SCHEMBL10534693 | 0.76 | CYP19A1 (0.47) | CYP19A1SGPL1S1PR1CYP24A1THRA | |
| SCHEMBL8465475 | 0.76 | CYP19A1 (0.78) | CYP19A1CYP26A1CYP24A1ESR1ESR2 | |
| SCHEMBL6272342 | 0.75 | CYP19A1 (0.57) | CYP19A1THRATHRBHTR1A | |
| SCHEMBL10536475 | 0.75 | CYP19A1 (0.60) | CYP19A1ESR1ESR2THRATHRB | |
| SCHEMBL27919093 | 0.74 | CYP19A1 (0.56) | CYP19A1THRATHRBHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6166031-A | Substituted tetralins, chromans and related compounds in the treatment of asthma | PFIZER INC, (US) | 2000-12-26 | — | — | US | disclosed |
| EP-0288962-B1 | Aryl-aralkyl ethers, processes for their preparation and pharmaceutical composition comprising them | FUJISAWA PHARMACEUTICAL CO (JP) | 1994-07-13 | — | — | EP | disclosed |
| CN-1024663-C | Substituted tetralins for treating asthma | PFIZER (US) | 1994-05-25 | — | — | CN | disclosed |
| US-5061718-A | BENZOTHIAZOLYLMETHOXY COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME AND THEIR USE AS ANTI-INFLAMMATORY OR ANTI-ALLERGENIC AGENTS | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1991-10-29 | — | — | US | disclosed |
| US-5045548-A | Lipoxygenase inhibitors | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1991-09-03 | — | — | US | disclosed |
| CN-1013442-B | BICYCLIC COMPOUND PROCESSES FOR PREPN. THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | FUJISAWA PHARMACEUTICAL CO (JP) | 1991-08-07 | — | — | CN | disclosed |
| US-4965274-A | Antiallergen, antiinflammatory agent; lipoxygenase | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1990-10-23 | — | — | US | disclosed |
| US-4923881-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS | Fujisawa Phatmaceutical Co., Ltd. (JP) | 1990-05-08 | — | — | US | disclosed |
| CN-1033277-A | Substituted tetralinchromans and related compounds for the treatment of asthma | PFIZER (US) | 1989-06-07 | — | — | CN | disclosed |
| WO-1989003681-A1 | SUBSTITUTED TETRALINS, CHROMANS AND RELATED COMPOUNDS IN THE TREATMENT OF ASTHMA | PFIZER INC. (US) | 1989-05-05 | — | — | WO | disclosed |
| EP-0313296-A2 | Substituted chromans and related compounds in the treatment of asthma | PFIZER INC. (US) | 1989-04-26 | — | — | EP | disclosed |
| CN-88102538-A | New dicyclic compound, its preparation method and the pharmaceutical composition that contains this compounds | — | 1988-12-07 | — | — | CN | disclosed |
| EP-0288962-A2 | Aryl-aralkyl ethers, processes for their preparation and pharmaceutical composition comprising them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-11-02 | — | — | EP | disclosed |