Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Cyclohexylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 10/20 | 0.44 |
| ▸ | MEN1 | O00255 | 8/20 | 0.44 |
| ▸ | NPC1 | O15118 | 8/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | CD74 | P04233 | 1/20 | 0.40 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | NCF1 | P14598 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclohexylamine SCHEMBL7792748 | 0.92 | KDM4E (0.49) | KMT2AMEN1NPC1KDM4ERAB9A | |
| Cyclohexylamine SCHEMBL8025671 | 0.88 | KMT2A (0.40) | KMT2AMEN1NPC1KDM4ERAB9A | |
| Cyclohexylamine SCHEMBL8025677 | 0.88 | KMT2A (0.40) | KMT2AMEN1NPC1KDM4ERAB9A | |
| Lysine SCHEMBL8035596 | 0.84 | GSR (0.38) | KMT2AMEN1NPC1KDM4ERAB9A | |
| Lysine SCHEMBL8035593 | 0.84 | GSR (0.38) | KMT2AMEN1NPC1KDM4ERAB9A | |
| Cyclohexylamine SCHEMBL7798429 | 0.83 | KDM4E (0.44) | NPC1KDM4ERAB9ASMN1; SMN2POLB | |
| Cyclohexylamine SCHEMBL8039390 | 0.82 | TSHR (0.36) | KMT2AMEN1NPC1KDM4ERAB9A | |
| SCHEMBL29694379 | 0.78 | KDM4E (0.64) | KMT2AMEN1NPC1KDM4ERAB9A | |
| SCHEMBL29406155 | 0.78 | KDM4E (0.64) | KMT2AMEN1NPC1KDM4ERAB9A | |
| SCHEMBL279696 | 0.78 | KDM4E (0.64) | KMT2AMEN1NPC1KDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |