Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8050562 | 0.89 | NAMPT (0.57) | NAMPTCYP2C19SIGMAR1DRD2KMT2A | |
| SCHEMBL8044952 | 0.89 | L3MBTL1 (0.47) | NPC1RAB9ASIGMAR1DRD2DRD3 | |
| SCHEMBL8046351 | 0.88 | NPC1 (0.51) | NAMPTNPC1RAB9AALDH1A1DRD2 | |
| SCHEMBL8035856 | 0.87 | NAMPT (0.50) | NAMPTNPC1RAB9AALDH1A1DRD2 | |
| Hydrochloric Acid SCHEMBL8152540 | 0.87 | NPC1 (0.50) | NAMPTNPC1RAB9AALDH1A1DRD2 | |
| SCHEMBL8045208 | 0.86 | NAMPT (0.52) | NAMPTNPC1RAB9ASIGMAR1DRD2 | |
| SCHEMBL8045277 | 0.86 | NPC1 (0.51) | NAMPTNPC1RAB9AALDH1A1SIGMAR1 | |
| SCHEMBL8035863 | 0.84 | NAMPT (0.53) | NAMPTNPC1RAB9ASIGMAR1SMN1; SMN2 | |
| SCHEMBL8655180 | 0.84 | HDAC3 (0.52) | CYP1A2CYP2D6CYP2C19SIGMAR1DRD2 | |
| SCHEMBL8045607 | 0.84 | NAMPT (0.49) | NAMPTNPC1RAB9ASIGMAR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0679649-B1 | 2,3-Dihydrobenzofuran Derivatives | ASAHI CHEMICAL IND (JP) | 2000-04-26 | — | — | EP | claimed |
| EP-0679649-B1 | 2,3-Dihydrobenzofuran Derivatives | ASAHI CHEMICAL IND (JP) | 2000-04-26 | — | — | EP | disclosed |
| EP-0679649-A1 | 2,3-DIHYDROBENZOFURAN DERIVATIVE | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1995-11-02 | — | — | EP | disclosed |