Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 6/20 | 0.49 |
| ▸ | DRD4 | P21917 | 6/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CCR3 | P51677 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8035644 | 0.89 | NAMPT (0.54) | NAMPTSIGMAR1DRD2HPGDMEN1 | |
| SCHEMBL8035576 | 0.87 | HPGD (0.47) | NAMPTHPGDMEN1KMT2AOPRM1 | |
| SCHEMBL8046351 | 0.86 | NPC1 (0.51) | NAMPTDRD2DRD4HPGD | |
| SCHEMBL8045257 | 0.85 | NAMPT (0.55) | NAMPTHPGDGAAOPRM1CYP2C9 | |
| SCHEMBL8045463 | 0.85 | NAMPT (0.57) | NAMPTDRD2DRD4GAA | |
| Hydrochloric Acid SCHEMBL8152540 | 0.85 | NPC1 (0.50) | NAMPTDRD2DRD4HPGD | |
| SCHEMBL8035856 | 0.85 | NAMPT (0.50) | NAMPTDRD2DRD4HPGD | |
| SCHEMBL8655180 | 0.84 | HDAC3 (0.52) | SIGMAR1DRD2DRD4OPRM1CYP2C19 | |
| SCHEMBL8045277 | 0.83 | NPC1 (0.51) | NAMPTSIGMAR1HPGD | |
| SCHEMBL8048246 | 0.83 | NAMPT (0.57) | NAMPTDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0679649-B1 | 2,3-Dihydrobenzofuran Derivatives | ASAHI CHEMICAL IND (JP) | 2000-04-26 | — | — | EP | claimed |
| EP-0679649-B1 | 2,3-Dihydrobenzofuran Derivatives | ASAHI CHEMICAL IND (JP) | 2000-04-26 | — | — | EP | disclosed |
| EP-0679649-A1 | 2,3-DIHYDROBENZOFURAN DERIVATIVE | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1995-11-02 | — | — | EP | disclosed |