Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | PPARA | Q07869 | 2/20 | 0.34 |
| ▸ | KIF11 | P52732 | 2/20 | 0.34 |
| ▸ | CPB2 | Q96IY4 | 3/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL8035739 | 1.00 | GSR (0.40) | GSRDPP8DPP7DPP9PPARG | |
| Cyclohexylamine SCHEMBL8037314 | 0.89 | KIF11 (0.37) | PPARGPPARAKIF11TSHRKMT2A | |
| Cyclohexylamine SCHEMBL8037307 | 0.89 | KIF11 (0.37) | PPARGPPARAKIF11TSHRKMT2A | |
| Lysine SCHEMBL8035596 | 0.85 | GSR (0.38) | GSRDPP8DPP7PPARGPPARA | |
| Lysine SCHEMBL8035593 | 0.85 | GSR (0.38) | GSRDPP8DPP7PPARGPPARA | |
| Cyclohexylamine SCHEMBL8039390 | 0.83 | TSHR (0.36) | PPARGPPARATSHRKMT2A | |
| Lysine SCHEMBL8039122 | 0.81 | GSR (0.48) | GSRDPP8DPP7DPP9KIF11 | |
| Lysine SCHEMBL8035117 | 0.79 | PPARG (0.42) | GSRDPP8DPP7DPP9PPARG | |
| Lysine SCHEMBL8035120 | 0.79 | PPARG (0.42) | GSRDPP8DPP7DPP9PPARG | |
| Lysine SCHEMBL8037280 | 0.78 | GSR (0.43) | GSRDPP8DPP7DPP9KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |