Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S100A4 | P26447 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | CASP6 | P55212 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1253991 | 0.79 | MAPT (0.38) | S100A4MEN1KMT2AMAPTNPC1 | |
| SCHEMBL837902 | 0.79 | MAPT (0.35) | CTSBMEN1KMT2AMAPTNPC1 | |
| SCHEMBL1965937 | 0.78 | TSHR (0.42) | MAPTALDH1A1KDM4EPTGS2ELANE | |
| SCHEMBL2723844 | 0.76 | ELANE (0.51) | MAPTNPC1RAB9ALMNAALDH1A1 | |
| SCHEMBL2267753 | 0.76 | HSD17B10 (0.49) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL3802279 | 0.69 | POLB (0.39) | MAPTLMNAALDH1A1HTTKDM4E | |
| SCHEMBL12998307 | 0.67 | KDM4E (0.47) | MAPTALDH1A1HTTKDM4EHTR2C | |
| SCHEMBL19798248 | 0.67 | GPR3 (0.34) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL3557147 | 0.66 | MAPT (0.46) | S100A4MEN1KMT2AMAPTNPC1 | |
| SCHEMBL11009351 | 0.64 | ELANE (0.64) | KMT2AELANEGAAP2RX4RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1305462-A | 1,5 and 3-O-substituted 1H-indazoles with antiasthmatic, antiallergic, antiinflammatory, immunomodulating and neuroprotective action, process for their preparation and their use as medicaments | DRESDEN ARZNEIMITTEL (DE) | 2001-07-25 | — | — | CN | disclosed |
| US-6166023-A | 1,5- and 3-O-substituted 1H-indazoles having anti-asthmatic, anti-allergic, anti-inflammatory, immunomodulating and neuroprotective action, process for their preparation and their use as medicaments | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 2000-12-26 | — | — | US | disclosed |
| US-5776932-A | ANTIALLERGENS, ANTIASTHMATICS, ANTIINFLAMMATORY AGENTS AND MODULATORS | ARZNEIMITTELWERK DRESDEN G.M.B.H. (DE) | 1998-07-07 | — | — | US | disclosed |