Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.44 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.39 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.39 |
| ▸ | DPEP1 | P16444 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 5/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 3/20 | 0.34 |
| ▸ | CPB2 | Q96IY4 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | NTSR2 | O95665 | 1/20 | 0.33 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.33 |
| ▸ | FAP | Q12884 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL8037285 | 1.00 | GSR (0.44) | GSRGRIK1GRIK2DPEP1DPP8 | |
| Lysine SCHEMBL8035316 | 0.90 | GSR (0.46) | GSRDPP8DPP7DPP9DPP4 | |
| Lysine SCHEMBL8035311 | 0.90 | GSR (0.46) | GSRDPP8DPP7DPP9DPP4 | |
| Lysine SCHEMBL8039122 | 0.90 | GSR (0.48) | GSRDPP8DPP7DPP9CPB2 | |
| Lysine SCHEMBL8037528 | 0.89 | GSR (0.44) | GSRGRIK1GRIK2DPEP1DPP8 | |
| Lysine SCHEMBL8025620 | 0.89 | GSR (0.44) | GSRGRIK1GRIK2DPP8DPP7 | |
| Lysine SCHEMBL8037527 | 0.89 | GSR (0.44) | GSRGRIK1GRIK2DPEP1DPP8 | |
| Lysine SCHEMBL8025623 | 0.89 | GSR (0.44) | GSRGRIK1GRIK2DPP8DPP7 | |
| Lysine SCHEMBL8037742 | 0.88 | ALDH1A1 (0.42) | GSRDPP8DPP7DPP9CPB2 | |
| Lysine SCHEMBL8037738 | 0.88 | ALDH1A1 (0.42) | GSRDPP8DPP7DPP9CPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |