Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.44 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.39 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.38 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.38 |
| ▸ | DPEP1 | P16444 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 4/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CTSH | P09668 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL8037527 | 1.00 | GSR (0.44) | GSRDPP9CACNA1BGRIK1GRIK2 | |
| Lysine SCHEMBL8035316 | 0.90 | GSR (0.46) | GSRDPP9DPP8DPP7DPP4 | |
| Lysine SCHEMBL8035311 | 0.90 | GSR (0.46) | GSRDPP9DPP8DPP7DPP4 | |
| Lysine SCHEMBL8039122 | 0.90 | GSR (0.48) | GSRDPP9DPP8DPP7KMT2A | |
| Lysine SCHEMBL8037288 | 0.89 | GSR (0.44) | GSRDPP9GRIK1GRIK2DPEP1 | |
| Lysine SCHEMBL8025623 | 0.89 | GSR (0.44) | GSRDPP9GRIK1GRIK2DPP8 | |
| Lysine SCHEMBL8037285 | 0.89 | GSR (0.44) | GSRDPP9GRIK1GRIK2DPEP1 | |
| Lysine SCHEMBL8025620 | 0.89 | GSR (0.44) | GSRDPP9GRIK1GRIK2DPP8 | |
| Lysine SCHEMBL8039357 | 0.88 | CTSB (0.42) | GSRDPP9CTSBCTSSDPP8 | |
| Lysine SCHEMBL8039360 | 0.88 | CTSB (0.42) | GSRDPP9CTSBCTSSDPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |