SCHEMBL8037672

SCHEMBL8037672

COCc1cc(-n2nc(C(F)(F)F)cc2-c2ccc(SC)cc2)ccc1S(C)(=O)=O

nearest known ligand 0.67

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 18/20 0.67
PTGS1 P23219 2/20 0.60
CYP2C9 P11712 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8023910 0.89 PTGS2 (0.84) PTGS2PTGS1CYP2C9
SCHEMBL8033659 0.85 PTGS2 (0.63) PTGS2PTGS1CYP2C9
SCHEMBL6516666 0.84 PTGS2 (0.61) PTGS2PTGS1CYP2C9
SCHEMBL8037379 0.83 PTGS2 (0.60) PTGS2PTGS1CYP2C9
SCHEMBL8954495 0.81 PTGS2 (0.81) PTGS2PTGS1CYP2C9
SCHEMBL8039820 0.80 PTGS2 (1.00) PTGS2PTGS1
SCHEMBL8040163 0.80 PTGS2 (0.83) PTGS2PTGS1
SCHEMBL8023471 0.79 PTGS2 (1.00) PTGS2PTGS1
SCHEMBL8036564 0.79 PTGS2 (0.86) PTGS2PTGS1
SCHEMBL8023531 0.78 PTGS2 (0.63) PTGS2PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2000066562-A1 PYRAZOLES HAVING ANTIINFLAMMATORY ACTIVITY DR. REDDY'S RESEARCH FOUNDATION (IN) 2000-11-09 WO claimed
WO-2000066562-A1 PYRAZOLES HAVING ANTIINFLAMMATORY ACTIVITY DR. REDDY'S RESEARCH FOUNDATION (IN) 2000-11-09 WO disclosed