SCHEMBL8038020

SCHEMBL8038020

Clc1cccc2sc(Sc3nnnn3Cc3ccccc3)nc12

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 3/20 0.44
HSP90AA1 P07900 1/20 0.43
HSP90AB1 P08238 1/20 0.43
ALDH1A1 P00352 8/20 0.42
KMT2A Q03164 6/20 0.42
MAPT P10636 5/20 0.42
MEN1 O00255 5/20 0.42
HPGD P15428 3/20 0.42
LMNA P02545 5/20 0.42
TSHR P16473 3/20 0.42
RAB9A P51151 1/20 0.42
HTT P42858 4/20 0.40
PKM P14618 2/20 0.40
MAPK1 P28482 1/20 0.40
NPSR1 Q6W5P4 3/20 0.40
HSD17B10 Q99714 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.39
GAA P10253 1/20 0.39
NPC1 O15118 1/20 0.39
PDE10A Q9Y233 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8033771 0.90 HSP90AA1 (0.43) P2RX7HSP90AA1HSP90AB1ALDH1A1KMT2A
SCHEMBL8050909 0.86 HSP90AA1 (0.48) P2RX7HSP90AA1HSP90AB1ALDH1A1KMT2A
SCHEMBL8042032 0.85 HSP90AA1 (0.40) HSP90AA1HSP90AB1ALDH1A1KMT2AMAPT
SCHEMBL8034157 0.84 AKR1B1 (0.42) HSP90AA1HSP90AB1ALDH1A1KMT2AMAPT
SCHEMBL8051988 0.84 HSP90AA1 (0.52) HSP90AA1HSP90AB1ALDH1A1KMT2AMAPT
SCHEMBL8042804 0.84 ALDH1A1 (0.49) HSP90AA1HSP90AB1ALDH1A1KMT2AMAPT
SCHEMBL8045150 0.83 ALDH1A1 (0.52) ALDH1A1KMT2AMAPTMEN1HPGD
SCHEMBL8048089 0.82 HSP90AA1 (0.57) HSP90AA1HSP90AB1ALDH1A1KMT2AMAPT
SCHEMBL8046039 0.80 HSP90AA1 (0.46) HSP90AA1HSP90AB1ALDH1A1KMT2AMAPT
SCHEMBL8047839 0.80 HSP90AA1 (0.46) HSP90AA1HSP90AB1ALDH1A1MAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6080772-A 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY SUGEN, INC. (US) 2000-06-27 US disclosed
WO-1998027092-A1 THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION SUGEN, INC. (US) 1998-06-25 WO disclosed