Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | UBE2M | P61081 | 1/20 | 0.35 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | F2RL3 | Q96RI0 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8713974 | 0.94 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1ALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL8048089 | 0.89 | HSP90AA1 (0.57) | HSP90AA1HSP90AB1ALDH1A1CYP2C19LMNA | |
| SCHEMBL8051988 | 0.86 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1ALDH1A1TP53CYP2C9 | |
| SCHEMBL8047839 | 0.86 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1ALDH1A1LMNAUBE2M | |
| SCHEMBL8050909 | 0.84 | HSP90AA1 (0.48) | HSP90AA1HSP90AB1ALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL8044756 | 0.83 | ALDH1A1 (0.47) | HSP90AA1HSP90AB1ALDH1A1TP53CYP2C9 | |
| SCHEMBL8034257 | 0.82 | HSP90AA1 (0.45) | HSP90AA1HSP90AB1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL8033771 | 0.81 | HSP90AA1 (0.43) | HSP90AA1HSP90AB1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL8051890 | 0.80 | HSP90AA1 (0.48) | HSP90AA1HSP90AB1ALDH1A1SMN1; SMN2THRB | |
| SCHEMBL8038020 | 0.80 | P2RX7 (0.44) | HSP90AA1HSP90AB1ALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |