Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.58 |
| ▸ | CTSL | P07711 | 6/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8038235 | 1.00 | ATM (0.58) | ATMMETTL3CTSLALDH1A1CTSK | |
| SCHEMBL8037943 | 0.87 | CTSL (0.59) | ATMMETTL3CTSLALDH1A1CTSK | |
| SCHEMBL8037941 | 0.87 | CTSL (0.59) | ATMMETTL3CTSLALDH1A1CTSK | |
| SCHEMBL8050447 | 0.85 | CTSL (0.54) | ATMMETTL3CTSLALDH1A1CTSK | |
| SCHEMBL8050449 | 0.85 | CTSL (0.54) | ATMMETTL3CTSLALDH1A1CTSK | |
| SCHEMBL8096306 | 0.83 | CTSL (0.57) | ATMMETTL3CTSLCTSB | |
| SCHEMBL8096310 | 0.83 | CTSL (0.57) | ATMMETTL3CTSLCTSB | |
| SCHEMBL940571 | 0.82 | CTSL (0.54) | ATMMETTL3CTSLCTSKCTSB | |
| SCHEMBL8037956 | 0.82 | CTSL (0.69) | ATMMETTL3CTSLALDH1A1CTSK | |
| SCHEMBL8037952 | 0.82 | CTSL (0.69) | ATMMETTL3CTSLALDH1A1CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998057926-A1 | ELEVATION OF HDL CHOLESTEROL BY N-[2-[ (AMINOTHIOXOMETHYL)HYDRAZONO] -2-ARYLETHYL]AMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-12-23 | — | — | WO | claimed |
| US-6049006-A | INCREASES PLASMA LEVELS OF HDL CHOLESTEROL AND AS SUCH USED FOR TREATING DISEASES SUCH AS ATHEROSCLEROSIS | AMERICAN HOME PRODUCTS CORP. (US) | 2000-04-11 | — | — | US | disclosed |
| WO-1998057926-A1 | ELEVATION OF HDL CHOLESTEROL BY N-[2-[ (AMINOTHIOXOMETHYL)HYDRAZONO] -2-ARYLETHYL]AMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |