SCHEMBL8038337

SCHEMBL8038337

CP(=O)(OCc1ccc(Br)cc1)OCc1ccc(Br)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 2/20 0.48
MAOB P27338 5/20 0.46
POLB P06746 1/20 0.43
CTDSP1 Q9GZU7 1/20 0.43
RXRA P19793 1/20 0.43
RXRB P28702 1/20 0.43
KDM4E B2RXH2 3/20 0.42
MAPT P10636 2/20 0.42
ALDH1A1 P00352 2/20 0.42
HPGD P15428 1/20 0.42
SMPD1 P17405 1/20 0.41
KMT2A Q03164 3/20 0.41
MEN1 O00255 1/20 0.41
APP P05067 1/20 0.40
TSHR P16473 1/20 0.39
MAOA P21397 2/20 0.39
CA12 O43570 1/20 0.39
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
CA7 P43166 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8038340 0.84 MAOB (0.47) IDO1MAOBPOLBCTDSP1RXRA
SCHEMBL8049199 0.82 IDO1 (0.44) IDO1MAOBPOLBCTDSP1RXRA
SCHEMBL7110551 0.80 IDO1 (0.45) IDO1MAOBPOLBCTDSP1RXRA
SCHEMBL5336792 0.79 TSHR (0.64) IDO1MAOBPOLBCTDSP1RXRA
SCHEMBL780501 0.79 IDO1 (0.48) IDO1MAOBALDH1A1KMT2AMEN1
SCHEMBL2301523 0.79 TSHR (0.48) IDO1MAOBPOLBCTDSP1RXRA
SCHEMBL389180 0.78 TSHR (0.63) IDO1MAOBKDM4EALDH1A1TSHR
SCHEMBL8049409 0.78 IDO1 (0.53) IDO1MAOBPOLBMAPTALDH1A1
SCHEMBL4586654 0.77 TSHR (0.54) IDO1MAOBPOLBCTDSP1RXRA
SCHEMBL28402768 0.76 KMT2A (0.55) MAOBMAPTALDH1A1HPGDKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6043341-A PHOSPHONYLATING AGENTS FOR REGIOSELECTIVE AND REPRODUCIBLE CONVERSION OF PEPTIDES TO PHOSPHONIC ACID PRODRUGS ELI LILLY & CO. (US) 2000-03-28 US disclosed
EP-0906915-A1 Preparation of cyclic peptide antifungal agents ELI LILLY AND COMPANY (US) 1999-04-07 EP disclosed
WO-1999006062-A1 CYCLIC PEPTIDE ANTIFUNGAL AGENTS ELI LILLY AND COMPANY (US) 1999-02-11 WO disclosed