Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.53 |
| ▸ | AGXT | P21549 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 5/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8056267 | 0.83 | ALDH1A1 (0.50) | IDO1AGXTALDH1A1HTTNPC1 | |
| SCHEMBL20840419 | 0.82 | IDO1 (0.57) | IDO1AGXTALDH1A1HTTNPC1 | |
| SCHEMBL8389200 | 0.82 | NPC1 (0.53) | IDO1AGXTALDH1A1HTTNPC1 | |
| SCHEMBL5335331 | 0.82 | TSHR (0.60) | IDO1AGXTALDH1A1HTTNPC1 | |
| SCHEMBL1369690 | 0.81 | IDO1 (0.50) | IDO1AGXTALDH1A1HTTNPC1 | |
| SCHEMBL5521298 | 0.79 | IDO1 (0.48) | IDO1AGXTALDH1A1HTTNPC1 | |
| SCHEMBL158785 | 0.78 | LMNA (0.48) | ALDH1A1HTTNPC1RAB9APOLB | |
| SCHEMBL780501 | 0.78 | IDO1 (0.48) | IDO1AGXTALDH1A1APPMAOB | |
| SCHEMBL8038337 | 0.78 | IDO1 (0.48) | IDO1ALDH1A1POLBMAPTAPP | |
| SCHEMBL389180 | 0.77 | TSHR (0.63) | IDO1AGXTALDH1A1MAOBCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6043341-A | PHOSPHONYLATING AGENTS FOR REGIOSELECTIVE AND REPRODUCIBLE CONVERSION OF PEPTIDES TO PHOSPHONIC ACID PRODRUGS | ELI LILLY & CO. (US) | 2000-03-28 | — | — | US | disclosed |
| EP-0906915-A1 | Preparation of cyclic peptide antifungal agents | ELI LILLY AND COMPANY (US) | 1999-04-07 | — | — | EP | disclosed |