Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.58 |
| ▸ | IDO1 | P14902 | 2/20 | 0.48 |
| ▸ | RXRA | P19793 | 1/20 | 0.47 |
| ▸ | RXRB | P28702 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.41 |
| ▸ | OGG1 | O15527 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9138596 | 0.93 | TSHR (0.79) | TSHRAKR1C3IDO1RXRARXRB | |
| SCHEMBL27541457 | 0.88 | TSHR (0.48) | TSHRAKR1C3IDO1RXRARXRB | |
| SCHEMBL8038340 | 0.84 | MAOB (0.47) | TSHRAKR1C3IDO1RXRARXRB | |
| SCHEMBL31326220 | 0.83 | TSHR (0.69) | TSHRAKR1C3IDO1KMT2ASRC | |
| SCHEMBL8038337 | 0.79 | IDO1 (0.48) | TSHRIDO1RXRARXRBMAOB | |
| SCHEMBL21749217 | 0.79 | TSHR (0.64) | TSHRAKR1C3IDO1MAOBALDH1A1 | |
| SCHEMBL9138537 | 0.79 | TSHR (0.64) | TSHRAKR1C3MAOBBTN3A1MAPT | |
| SCHEMBL27908642 | 0.78 | TSHR (1.00) | TSHRAKR1C3ALDH1A1SRC | |
| SCHEMBL51316 | 0.78 | TSHR (1.00) | TSHRAKR1C3ALDH1A1SRC | |
| SCHEMBL4219700 | 0.77 | TSHR (0.96) | TSHRAKR1C3ALDH1A1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235666-B2 | Sulfonation of 3-(hydroxymethyl)-5,5-diphenylimidazolidine-2,4-dione followed by phosphating in the presence of trisubstituted aliphatic amine base and a polar aprotic solvent; anticonvulsants, antiepileptic and antiarrhythmia agent | CILAG LTD. (CH) | 2007-06-26 | — | — | US | claimed |
| US-7235666-B2 | Sulfonation of 3-(hydroxymethyl)-5,5-diphenylimidazolidine-2,4-dione followed by phosphating in the presence of trisubstituted aliphatic amine base and a polar aprotic solvent; anticonvulsants, antiepileptic and antiarrhythmia agent | CILAG LTD. (CH) | 2007-06-26 | — | — | US | disclosed |
| US-20050272706-A1 | Process for the preparation of sodium fosphenytoin | CILAG, LTD. | 2005-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272706-A1 | Process for the preparation of sodium fosphenytoin | FOS, DUSP5, DCPS | TSHR 3700/4885AKR1C3 1482/4885IDO1 3664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.