Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.53 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | GBA1 | P04062 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | BACE1 | P56817 | 2/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12383 | 0.83 | ALDH1A1 (0.55) | S1PR1S1PR5LMNAALDH1A1POLB | |
| SCHEMBL3107774 | 0.82 | ALDH1A1 (0.52) | S1PR5ALDH1A1MEN1KMT2AHRH3 | |
| SCHEMBL17850378 | 0.81 | S1PR1 (0.50) | S1PR1S1PR5LMNAALDH1A1POLB | |
| SCHEMBL13229557 | 0.81 | S1PR5 (0.46) | S1PR5MAPTACHEBACE1BCHE | |
| SCHEMBL2432513 | 0.80 | SMN1; SMN2 (0.58) | ALDH1A1MAPT | |
| SCHEMBL2114892 | 0.80 | FUCA1 (0.58) | S1PR1S1PR5ALDH1A1GBA1ACHE | |
| SCHEMBL11337029 | 0.80 | FUCA1 (0.58) | S1PR1S1PR5ALDH1A1GBA1ACHE | |
| SCHEMBL11337025 | 0.80 | FUCA1 (0.58) | S1PR1S1PR5ALDH1A1GBA1ACHE | |
| SCHEMBL17285918 | 0.78 | S1PR1 (0.54) | S1PR1S1PR5LMNAALDH1A1POLB | |
| SCHEMBL22254430 | 0.78 | S1PR1 (0.54) | S1PR1S1PR5LMNAALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227476-B1 | TRICYCLIC TRIAZOLIC COMPOUNDS | ESTEVE LABOR DR (ES) | 2011-09-07 | — | — | EP | disclosed |
| EP-2070933-A1 | Tricyclic triazolic compounds | Laboratorios del Dr. Esteve S.A. (ES) | 2009-06-17 | — | — | EP | disclosed |
| WO-2009071657-A1 | TRICYCLIC TRIAZOLIC COMPOUNDS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2009-06-11 | — | — | WO | disclosed |