Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | PLG | P00747 | 1/20 | 0.36 |
| ▸ | PLAT | P00750 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 2/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 2/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | FAP | Q12884 | 1/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL8039338 | 1.00 | GSR (0.43) | GSRDPP8DPP7DPP9F2 | |
| Lysine SCHEMBL8035193 | 0.88 | GSR (0.43) | GSRDPP8DPP7DPP9F2 | |
| Lysine SCHEMBL8035194 | 0.88 | GSR (0.43) | GSRDPP8DPP7DPP9F2 | |
| Cyclohexylamine SCHEMBL8035751 | 0.88 | KIF11 (0.39) | KMT2AKIF11 | |
| Cyclohexylamine SCHEMBL8035749 | 0.88 | KIF11 (0.39) | KMT2AKIF11 | |
| Lysine SCHEMBL8039122 | 0.85 | GSR (0.48) | GSRDPP8DPP7DPP9F2 | |
| Lysine SCHEMBL8035120 | 0.85 | PPARG (0.42) | GSRDPP8DPP7DPP9F2 | |
| Lysine SCHEMBL8035117 | 0.85 | PPARG (0.42) | GSRDPP8DPP7DPP9F2 | |
| Lysine SCHEMBL8039206 | 0.85 | GSR (0.40) | GSRDPP8DPP7DPP9F2 | |
| Lysine SCHEMBL8039205 | 0.85 | GSR (0.40) | GSRDPP8DPP7DPP9F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |