Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.66 |
| ▸ | RAB9A | P51151 | 5/20 | 0.66 |
| ▸ | NPC1 | O15118 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | TP53 | P04637 | 2/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | APP | P05067 | 2/20 | 0.50 |
| ▸ | MIF | P14174 | 1/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.50 |
| ▸ | CBFB | Q13951 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23954341 | 0.85 | KDM4E (0.77) | KDM4ERAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2949193 | 0.81 | MIF (0.70) | KDM4ERAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL29081219 | 0.81 | KDM4E (0.66) | KDM4ERAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3207351 | 0.81 | NPC1 (0.66) | KDM4ERAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL221431 | 0.80 | NPC1 (1.00) | KDM4ERAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2914054 | 0.79 | APP (0.66) | KDM4ERAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3202055 | 0.79 | NPC1 (0.57) | KDM4ERAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8050339 | 0.78 | RAB9A (0.60) | KDM4ERAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3201513 | 0.76 | KDM4E (0.54) | KDM4ERAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8358031 | 0.75 | KDM4E (0.53) | KDM4ERAB9ANPC1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130217-A | ANTITUMOR | PFIZER INC (US) | 2000-10-10 | — | — | US | disclosed |
| WO-1994022846-A1 | COMPOUNDS ENHANCING ANTITUMOR ACTIVITY OF OTHER CYTOTOXIC AGENTS | PFIZER INC. (US) | 1994-10-13 | — | — | WO | disclosed |