Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | NPC1 | O15118 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | DYRK1A | Q13627 | 9/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11782932 | 0.90 | RAB9A (0.63) | RAB9ASMN1; SMN2NPC1KDM4EALDH1A1 | |
| SCHEMBL23954341 | 0.81 | KDM4E (0.77) | RAB9ASMN1; SMN2NPC1KDM4EALDH1A1 | |
| SCHEMBL8359494 | 0.81 | KDM4E (0.50) | RAB9ASMN1; SMN2NPC1KDM4EALDH1A1 | |
| SCHEMBL2954313 | 0.80 | MIF (0.65) | RAB9ASMN1; SMN2NPC1KDM4EALDH1A1 | |
| SCHEMBL20068807 | 0.79 | SMN1; SMN2 (0.50) | RAB9ASMN1; SMN2NPC1KDM4EALDH1A1 | |
| SCHEMBL11780136 | 0.79 | KDM4E (0.55) | RAB9ASMN1; SMN2NPC1KDM4EALDH1A1 | |
| SCHEMBL8054624 | 0.78 | ALDH1A1 (0.51) | RAB9ASMN1; SMN2NPC1KDM4EALDH1A1 | |
| SCHEMBL8040079 | 0.78 | KDM4E (0.66) | RAB9ASMN1; SMN2NPC1KDM4EALDH1A1 | |
| SCHEMBL29081219 | 0.78 | KDM4E (0.66) | RAB9ASMN1; SMN2NPC1KDM4EALDH1A1 | |
| SCHEMBL3207351 | 0.78 | NPC1 (0.66) | RAB9ASMN1; SMN2NPC1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130217-A | ANTITUMOR | PFIZER INC (US) | 2000-10-10 | — | — | US | disclosed |
| WO-1994022846-A1 | COMPOUNDS ENHANCING ANTITUMOR ACTIVITY OF OTHER CYTOTOXIC AGENTS | PFIZER INC. (US) | 1994-10-13 | — | — | WO | disclosed |