Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | GSR | P00390 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.37 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 2/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
| ▸ | MC5R | P33032 | 1/20 | 0.36 |
| ▸ | MC3R | P41968 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL7800559 | 1.00 | ENPP2 (0.39) | ENPP2GSRDRD2DRD4ABCC4 | |
| Lysine SCHEMBL7800562 | 1.00 | ENPP2 (0.39) | ENPP2GSRDRD2DRD4ABCC4 | |
| Phenylacetic Acid SCHEMBL7801510 | 0.97 | ENPP2 (0.39) | ENPP2GSRDRD2DRD4ABCC4 | |
| Phenylacetic Acid SCHEMBL7801513 | 0.97 | ENPP2 (0.39) | ENPP2GSRDRD2DRD4ABCC4 | |
| Lysine SCHEMBL7800895 | 0.93 | GSR (0.43) | GSRDRD2DRD4GRIN1GRIN2A | |
| Lysine SCHEMBL7798348 | 0.93 | GSR (0.43) | GSRDRD2DRD4GRIN1GRIN2A | |
| Lysine SCHEMBL7792738 | 0.93 | GSR (0.43) | GSRDRD2DRD4GRIN1GRIN2A | |
| Lysine SCHEMBL7792734 | 0.93 | GSR (0.43) | GSRDRD2DRD4GRIN1GRIN2A | |
| Lysine SCHEMBL7802269 | 0.92 | GSR (0.41) | GSRDRD2DRD4GRIN1GRIN2A | |
| Lysine SCHEMBL7802023 | 0.92 | GSR (0.41) | GSRDRD2DRD4GRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |