Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 18/20 | 0.81 |
| ▸ | HRH1 | P35367 | 16/20 | 0.81 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.67 |
| ▸ | HTR2A | P28223 | 3/20 | 0.67 |
| ▸ | HTR2C | P28335 | 3/20 | 0.67 |
| ▸ | HTR7 | P34969 | 3/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.67 |
| ▸ | DRD2 | P14416 | 2/20 | 0.62 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.58 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.58 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.58 |
| ▸ | BCHE | P06276 | 1/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.58 |
| ▸ | ACHE | P22303 | 1/20 | 0.58 |
| ▸ | HRH2 | P25021 | 1/20 | 0.58 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.58 |
| ▸ | HTR1D | P28221 | 1/20 | 0.58 |
| ▸ | HTR1E | P28566 | 1/20 | 0.58 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8036359 | 0.93 | HTR6 (0.70) | HTR6HRH1ADRA2AHTR2AHTR2C | |
| SCHEMBL8031143 | 0.90 | HTR6 (1.00) | HTR6HRH1ADRA2AHTR2AHTR2C | |
| SCHEMBL8036730 | 0.89 | HTR6 (0.80) | HTR6HRH1ADRA2AHTR2AHTR2C | |
| SCHEMBL8044408 | 0.88 | HTR6 (0.67) | HTR6HRH1ADRA2AHTR2AHTR2C | |
| SCHEMBL8034682 | 0.84 | HTR6 (0.88) | HTR6HRH1ADRA2AHTR2AHTR2C | |
| SCHEMBL8032473 | 0.84 | HTR6 (0.88) | HTR6HRH1ADRA2AHTR2AHTR2C | |
| SCHEMBL12881949 | 0.84 | HTR6 (0.83) | HTR6HRH1ADRA2AHTR2AHTR2C | |
| SCHEMBL13696256 | 0.83 | HTR6 (0.79) | HTR6HRH1ADRA2AHTR2AHTR2C | |
| SCHEMBL3715259 | 0.82 | HTR6 (1.00) | HTR6HRH1ADRA2AHTR2AHTR2C | |
| SCHEMBL4140538 | 0.80 | HTR6 (0.81) | HTR6HRH1ADRA2AHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009082268-A2 | LIGANDS OF α-ADRENOCEPTORS AND OF DOPAMINE, HISTAMINE, IMIDAZOLINE AND SEROTONIN RECEPTORS AND THE USE THEREOF | ALLA CHEM, LLC (US) | 2009-07-02 | — | — | WO | disclosed |