Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.42 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.41 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 6/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 5/20 | 0.39 |
| ▸ | DPP4 | P27487 | 4/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.36 |
| ▸ | KDM1A | O60341 | 2/20 | 0.35 |
| ▸ | FAP | Q12884 | 1/20 | 0.34 |
| ▸ | NNMT | P40261 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CTSC | P53634 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL8041475 | 1.00 | GSR (0.42) | GSRGRIK1GRIK2DPP7DPP8 | |
| Lysine SCHEMBL8025651 | 0.89 | GRM4 (0.41) | GSRDPP7DPP8DPP4DPP9 | |
| Lysine SCHEMBL8025646 | 0.89 | GRM4 (0.41) | GSRDPP7DPP8DPP4DPP9 | |
| Cyclohexylamine SCHEMBL8035890 | 0.88 | GRIK1 (0.45) | GRIK1GRIK2DPP7DPP8DPP4 | |
| Cyclohexylamine SCHEMBL8035887 | 0.88 | GRIK1 (0.45) | GRIK1GRIK2DPP7DPP8DPP4 | |
| Lysine SCHEMBL8035311 | 0.87 | GSR (0.46) | GSRDPP7DPP8DPP4DPP9 | |
| Lysine SCHEMBL8035316 | 0.87 | GSR (0.46) | GSRDPP7DPP8DPP4DPP9 | |
| Lysine SCHEMBL8039122 | 0.87 | GSR (0.48) | GSRDPP7DPP8DPP9 | |
| Lysine SCHEMBL8025620 | 0.86 | GSR (0.44) | GSRGRIK1GRIK2DPP7DPP8 | |
| Lysine SCHEMBL8037285 | 0.86 | GSR (0.44) | GSRGRIK1GRIK2DPP7DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |