Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | GSR | P00390 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 6/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 5/20 | 0.37 |
| ▸ | DPP4 | P27487 | 4/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.37 |
| ▸ | FAP | Q12884 | 1/20 | 0.37 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | CTSC | P53634 | 1/20 | 0.34 |
| ▸ | NNMT | P40261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL8025646 | 1.00 | GRM4 (0.41) | GRM4GSRTSHREPHX1DPP7 | |
| Lysine SCHEMBL8041475 | 0.89 | GSR (0.42) | GSREPHX1DPP7DPP8DPP4 | |
| Lysine SCHEMBL8041477 | 0.89 | GSR (0.42) | GSREPHX1DPP7DPP8DPP4 | |
| Cyclohexylamine SCHEMBL8037502 | 0.89 | TSHR (0.42) | GRM4TSHREPHX1DPP7KMT2A | |
| Cyclohexylamine SCHEMBL8037499 | 0.89 | TSHR (0.42) | GRM4TSHREPHX1DPP7KMT2A | |
| Lysine SCHEMBL8039122 | 0.86 | GSR (0.48) | GSRDPP7KMT2ADPP8DPP9 | |
| Lysine SCHEMBL8037280 | 0.86 | GSR (0.43) | GSRDPP7KMT2ADPP8DPP9 | |
| Lysine SCHEMBL8037277 | 0.86 | GSR (0.43) | GSRDPP7KMT2ADPP8DPP9 | |
| 3-Formylbenzoic Acid SCHEMBL8039147 | 0.85 | UNG (0.48) | GRM4GSREPHX1DPP7 | |
| 3-Formylbenzoic Acid SCHEMBL8039145 | 0.85 | UNG (0.48) | GRM4GSREPHX1DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |