Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.39 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.37 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.35 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | FDPS | P14324 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL8041481 | 1.00 | GSR (0.39) | GSRGRIK1GRIK2KDM4ESMN1; SMN2 | |
| Lysine SCHEMBL8039183 | 0.90 | GSR (0.39) | GSRGRIK1GRIK2KDM4ESMN1; SMN2 | |
| Lysine SCHEMBL8039180 | 0.90 | GSR (0.39) | GSRGRIK1GRIK2KDM4ESMN1; SMN2 | |
| Isovanillin SCHEMBL8041270 | 0.90 | ALDH1A1 (0.48) | GSRGRIK1GRIK2KDM4ESMN1; SMN2 | |
| Isovanillin SCHEMBL8041267 | 0.90 | ALDH1A1 (0.48) | GSRGRIK1GRIK2KDM4ESMN1; SMN2 | |
| Cyclohexylamine SCHEMBL8025659 | 0.89 | GRIK1 (0.40) | GRIK1GRIK2KDM4ESMN1; SMN2TSHR | |
| Cyclohexylamine SCHEMBL8025661 | 0.89 | GRIK1 (0.40) | GRIK1GRIK2KDM4ESMN1; SMN2TSHR | |
| Lysine SCHEMBL8041442 | 0.85 | GSR (0.43) | GSRCPB2DPP8 | |
| Lysine SCHEMBL8041446 | 0.85 | GSR (0.43) | GSRCPB2DPP8 | |
| Cyclohexylamine SCHEMBL7798563 | 0.85 | ALDH1A1 (0.42) | KDM4ESMN1; SMN2TSHRNPC1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |