Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.37 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.35 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.35 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL8039180 | 1.00 | GSR (0.39) | GSRALDH1A1HTTHPGDKMT2A | |
| Isovanillin SCHEMBL8041267 | 0.90 | ALDH1A1 (0.48) | GSRALDH1A1HTTHPGDKMT2A | |
| Isovanillin SCHEMBL8041270 | 0.90 | ALDH1A1 (0.48) | GSRALDH1A1HTTHPGDKMT2A | |
| Lysine SCHEMBL8041480 | 0.90 | GSR (0.39) | GSRALDH1A1HTTHPGDKMT2A | |
| Lysine SCHEMBL8041481 | 0.90 | GSR (0.39) | GSRALDH1A1HTTHPGDKMT2A | |
| Cyclohexylamine SCHEMBL7800101 | 0.86 | ALDH1A1 (0.42) | ALDH1A1HTTHPGDKMT2AMEN1 | |
| Lysine SCHEMBL8037528 | 0.85 | GSR (0.44) | GSRALDH1A1KMT2AGRIK1GRIK2 | |
| Lysine SCHEMBL8037527 | 0.85 | GSR (0.44) | GSRALDH1A1KMT2AGRIK1GRIK2 | |
| Cyclohexylamine SCHEMBL7792102 | 0.83 | ALDH1A1 (0.49) | ALDH1A1HPGDKMT2AMEN1POLB | |
| Lysine SCHEMBL8041461 | 0.82 | KDM4E (0.40) | GSRALDH1A1HTTHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |