Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 16/20 | 0.53 |
| ▸ | MAOA | P21397 | 15/20 | 0.53 |
| ▸ | MAOB | P27338 | 15/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21066062 | 1.00 | KDM1A (0.53) | KDM1AMAOAMAOBMAPK1CYP2C19 | |
| SCHEMBL874954 | 1.00 | KDM1A (0.53) | KDM1AMAOAMAOBMAPK1CYP2C19 | |
| SCHEMBL21066065 | 1.00 | KDM1A (0.53) | KDM1AMAOAMAOBMAPK1CYP2C19 | |
| SCHEMBL2766130 | 1.00 | KDM1A (0.53) | KDM1AMAOAMAOBMAPK1CYP2C19 | |
| SCHEMBL4739718 | 1.00 | KDM1A (0.53) | KDM1AMAOAMAOBMAPK1CYP2C19 | |
| Hydrochloric Acid SCHEMBL28632580 | 0.98 | KDM1A (0.55) | KDM1AMAOAMAOB | |
| Hydrochloric Acid SCHEMBL2073275 | 0.98 | KDM1A (0.55) | KDM1AMAOAMAOB | |
| Trifluoroacetic Acid SCHEMBL14762539 | 0.90 | KDM1A (0.44) | KDM1AMAOAMAOBMAPK1CYP2C19 | |
| Trifluoroacetic Acid SCHEMBL13722853 | 0.90 | KDM1A (0.44) | KDM1AMAOAMAOBMAPK1CYP2C19 | |
| SCHEMBL901505 | 0.86 | KDM1A (0.52) | KDM1AMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110201581-A1 | Novel Compounds 010 | ASTRAZENECA AB (SE) | 2011-08-18 | — | — | US | disclosed |
| US-20110201581-A1 | Novel Compounds 010 | ASTRAZENECA AB (SE) | 2011-08-18 | — | — | US | disclosed |
| US-7902181-B2 | Compounds 010 | ASTRAZENECA AB (SE) | 2011-03-08 | — | — | US | disclosed |
| US-7902181-B2 | Compounds 010 | ASTRAZENECA AB (SE) | 2011-03-08 | — | — | US | disclosed |
| US-20090306042-A1 | Novel Compounds 010 | ASTRAZENECA AB (SE) | 2009-12-10 | — | — | US | disclosed |
| US-20090306042-A1 | Novel Compounds 010 | ASTRAZENECA AB (SE) | 2009-12-10 | — | — | US | disclosed |
| WO-2009074829-A1 | PEPTIDYL NITRILES AND USE THEREOF AS DIPEPTIDYL PEPTIDASE I INHIBITORS | ASTRAZENECA AB (SE) | 2009-06-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306042-A1 | Novel Compounds 010 | MRGPRX2, F12, TBXA2R | KDM1A 2795/4885MAOA 1604/4885MAOB 369/4885 |
| US-20110201581-A1 | Novel Compounds 010 | MRGPRX2, F12, TBXA2R | KDM1A 2795/4885MAOA 1604/4885MAOB 369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.