SCHEMBL8041968

SCHEMBL8041968

Fc1ccc(CNCC2CCCCC2)cc1

nearest known ligand 0.65

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.65
RAB9A P51151 2/20 0.65
POLB P06746 1/20 0.65
HDAC6 Q9UBN7 2/20 0.60
HDAC3 O15379 1/20 0.55
HDAC4 P56524 1/20 0.55
HDAC1 Q13547 1/20 0.55
HDAC8 Q9BY41 1/20 0.55
HDAC5 Q9UQL6 1/20 0.55
DPP7 Q9UHL4 2/20 0.53
ALDH1A1 P00352 2/20 0.53
LMNA P02545 2/20 0.50
SIGMAR1 Q99720 1/20 0.46
CHRM2 P08172 1/20 0.46
SSTR3 P32745 1/20 0.46
KDM4E B2RXH2 1/20 0.45
NPC1 O15118 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3861590 0.84 HDAC6 (0.62) SMN1; SMN2RAB9APOLBHDAC6HDAC3
SCHEMBL16480073 0.83 LMNA (0.49) SMN1; SMN2RAB9APOLBHDAC6DPP7
SCHEMBL18088394 0.82 RAB9A (0.60) SMN1; SMN2RAB9APOLBHDAC6HDAC3
SCHEMBL3085761 0.82 HDAC6 (0.60) SMN1; SMN2RAB9APOLBHDAC6HDAC3
SCHEMBL7248082 0.82 HDAC6 (0.60) SMN1; SMN2RAB9APOLBHDAC6HDAC3
SCHEMBL10764797 0.81 CXCR4 (0.63) RAB9AHDAC6HDAC3HDAC4HDAC1
SCHEMBL7603669 0.81 CXCR4 (0.63) RAB9AHDAC6HDAC3HDAC4HDAC1
Water SCHEMBL27599061 0.81 HDAC6 (0.59) SMN1; SMN2RAB9APOLBHDAC6HDAC3
Hydrochloric Acid SCHEMBL3857669 0.81 HDAC6 (0.59) SMN1; SMN2RAB9APOLBHDAC6HDAC3
SCHEMBL18306072 0.81 KMT2A (0.47) SMN1; SMN2RAB9APOLBHDAC6ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009071706-A1 PYRAZOLEPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES GALAPAGOS NV (BE) 2009-06-11 WO disclosed