Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | GRK6 | P43250 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 8/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8045981 | 0.81 | GRK6 (0.56) | KDM4EGRK6HPGDALDH1A1CYP1A2 | |
| SCHEMBL6746962 | 0.80 | GRK6 (0.46) | KDM4EGRK6HPGDALDH1A1CYP1A2 | |
| SCHEMBL8045261 | 0.80 | GRK6 (0.46) | KDM4EGRK6HPGDALDH1A1CYP1A2 | |
| SCHEMBL8043319 | 0.79 | KDM4E (0.53) | KDM4EGRK6HPGDALDH1A1CYP1A2 | |
| SCHEMBL8049958 | 0.76 | KDM4E (0.46) | KDM4EGRK6HPGDALDH1A1CYP1A2 | |
| SCHEMBL8043421 | 0.76 | KDM4E (0.50) | KDM4EGRK6HPGDALDH1A1CYP1A2 | |
| SCHEMBL8043954 | 0.75 | KDM4E (0.52) | KDM4EGRK6HPGDALDH1A1CYP1A2 | |
| SCHEMBL8049875 | 0.75 | GRK6 (0.49) | KDM4EGRK6HPGDALDH1A1CYP1A2 | |
| SCHEMBL8042995 | 0.75 | KDM4E (0.49) | KDM4EGRK6HPGDALDH1A1CYP1A2 | |
| SCHEMBL8042216 | 0.75 | KDM4E (0.46) | KDM4EGRK6HPGDALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |