Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | GRK6 | P43250 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 9/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | ILK | Q13418 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044112 | 0.81 | GRK6 (0.51) | KDM4EL3MBTL1NPC1RAB9AGRK6 | |
| SCHEMBL8049958 | 0.81 | KDM4E (0.46) | KDM4EL3MBTL1GRK6HPGDALDH1A1 | |
| SCHEMBL8051673 | 0.81 | SCD (0.46) | KDM4EL3MBTL1NPC1RAB9AGRK6 | |
| SCHEMBL8048199 | 0.81 | PDK1 (0.53) | KDM4EL3MBTL1GRK6HPGDALDH1A1 | |
| SCHEMBL8043421 | 0.79 | KDM4E (0.50) | KDM4EL3MBTL1NPC1RAB9AGRK6 | |
| SCHEMBL8032795 | 0.78 | HPGD (0.56) | KDM4EL3MBTL1RAB9AGRK6HPGD | |
| SCHEMBL8043319 | 0.76 | KDM4E (0.53) | KDM4EL3MBTL1NPC1RAB9AGRK6 | |
| SCHEMBL8044071 | 0.76 | ALDH1A1 (0.51) | KDM4EL3MBTL1RAB9AHPGDALDH1A1 | |
| SCHEMBL8043954 | 0.75 | KDM4E (0.52) | KDM4EL3MBTL1NPC1RAB9AGRK6 | |
| SCHEMBL8042483 | 0.75 | KDM4E (0.49) | KDM4EL3MBTL1NPC1RAB9AGRK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |