Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.42 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.39 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.38 |
| ▸ | CDK2 | P24941 | 4/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.38 |
| ▸ | CDK4 | P11802 | 2/20 | 0.38 |
| ▸ | CCND3 | P30281 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 3/20 | 0.37 |
| ▸ | JAK3 | P52333 | 3/20 | 0.37 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16404670 | 0.73 | JAK2 (0.49) | JAK2CAMK2DSTK17AGSK3BHDAC1 | |
| SCHEMBL8050523 | 0.73 | JAK2 (0.49) | JAK2CAMK2DSTK17AGSK3BHDAC1 | |
| SCHEMBL8058010 | 0.70 | MAPK8 (0.52) | JAK2JAK1JAK3TYK2MAPK8 | |
| SCHEMBL8052958 | 0.70 | JAK2 (0.39) | JAK2CCNA2CDK2CCNA1PIM1 | |
| SCHEMBL8052311 | 0.69 | MAPK10 (0.58) | JAK2STK17AMAPK8MAPK10 | |
| SCHEMBL3753865 | 0.67 | MAPK8 (0.63) | JAK2MTORJAK3MAPK8MAPK10 | |
| SCHEMBL3754395 | 0.66 | JAK2 (0.58) | JAK2CDK2CDK4MTORJAK1 | |
| SCHEMBL3748793 | 0.66 | MAPK10 (0.74) | JAK2MTORJAK3MAPK8MAPK10 | |
| SCHEMBL8051142 | 0.66 | MAPK8 (0.52) | JAK2STK17AJAK1JAK3TYK2 | |
| SCHEMBL8055715 | 0.65 | JAK2 (0.55) | JAK2CAMK2DSTK17AHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009032861-A1 | SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-03-12 | — | — | WO | disclosed |