Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.41 |
| ▸ | LMNA | P02545 | 7/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8052060 | 0.86 | MAPT (0.41) | MAPTPOLBALDH1A1LMNAKMT2A | |
| SCHEMBL8043940 | 0.86 | ALDH1A1 (0.43) | MAPTALDH1A1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL8044786 | 0.84 | ALDH1A1 (0.42) | MAPTPOLBALDH1A1LMNAKMT2A | |
| SCHEMBL8052220 | 0.84 | ALDH1A1 (0.54) | MAPTPOLBALDH1A1LMNAKMT2A | |
| SCHEMBL8048499 | 0.83 | KDM4E (0.49) | MAPTPOLBALDH1A1LMNAKMT2A | |
| SCHEMBL8034305 | 0.80 | KMT2A (0.51) | MAPTPOLBALDH1A1LMNAKMT2A | |
| SCHEMBL8048239 | 0.79 | ALDH1A1 (0.55) | MAPTPOLBALDH1A1LMNAKMT2A | |
| SCHEMBL8042219 | 0.79 | PTGS2 (0.44) | MAPTALDH1A1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL8047577 | 0.79 | SMN1; SMN2 (0.45) | MAPTALDH1A1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL8042535 | 0.78 | PTGS2 (0.44) | MAPTPOLBALDH1A1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |