Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 5/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.43 |
| ▸ | ALPG | P10696 | 1/20 | 0.42 |
| ▸ | CDC25A | P30304 | 1/20 | 0.42 |
| ▸ | CDC25B | P30305 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043271 | 0.85 | ALPG (0.45) | KMT2AMEN1ALPGCDC25ACDC25B | |
| SCHEMBL8032437 | 0.84 | ALPG (0.42) | KMT2AMEN1ALPGCDC25ACDC25B | |
| SCHEMBL8046022 | 0.83 | TP53 (0.45) | MAPK8MAPK9KMT2AMEN1NPC1 | |
| SCHEMBL8044593 | 0.83 | ALPG (0.42) | KMT2AMEN1ALPGCDC25ACDC25B | |
| SCHEMBL8033875 | 0.81 | MAPT (0.45) | KMT2AMEN1ALPGCDC25ACDC25B | |
| SCHEMBL8049866 | 0.80 | PKM (0.45) | KMT2AMEN1ALPGCDC25ACDC25B | |
| SCHEMBL7813813 | 0.79 | MAPK8 (0.46) | MAPK8MAPK9KMT2AMEN1NPC1 | |
| SCHEMBL8032745 | 0.79 | MEN1 (0.45) | KMT2AMEN1ALPGCDC25ACDC25B | |
| SCHEMBL7850363 | 0.79 | NPSR1 (0.49) | MAPK8MAPK9KMT2AMEN1NPC1 | |
| SCHEMBL8042964 | 0.78 | NPC1 (0.44) | MAPK8MAPK9KMT2AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |